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NCT ID: NCT02737501 Completed - Lung Cancer Clinical Trials

ALTA-1L Study: A Study of Brigatinib Versus Crizotinib in Anaplastic Lymphoma Kinase Positive (ALK+) Advanced Non-small Cell Lung Cancer (NSCLC) Participants

ALTA-1L
Start date: May 26, 2016
Phase: Phase 3
Study type: Interventional

The purpose of the study is to compare the efficacy of brigatinib to that of crizotinib in ALK+ locally advanced or metastatic non-small cell lung cancer (NSCLC) participants naive to ALK inhibitors, as evidenced by progression-free survival (PFS).

NCT ID: NCT02735044 Completed - Clinical trials for Type 1 Diabetes Mellitus

Comparison of the Safety and Efficacy of HOE901-U300 With Lantus in Children and Adolescents With Type 1 Diabetes Mellitus

EDITION JUNIOR
Start date: April 14, 2016
Phase: Phase 3
Study type: Interventional

Primary Objective: To compare the efficacy of a new formulation of insulin glargine (HOE901-U300) to Lantus in terms of change of HbA1c from baseline to endpoint (month 6) in children and adolescents with type 1 diabetes mellitus. . Secondary Objectives: To compare HOE901-U300 and Lantus in terms of: - Percentage of participants reaching target HbA1c and fasting plasma glucose (FPG). - To assess the safety of HOE901-U300 including analysis of events of hypoglycemia, events of hyperglycemia with ketosis, and development of anti-insulin-antibodies.

NCT ID: NCT02734563 Completed - Hernia, Abdominal Clinical Trials

Collagen Alterations in Patients With Abdominal Wall Hernias

Start date: January 2011
Phase: N/A
Study type: Observational

The aim of this study was to evaluate collagen turnover in patients with multiple hernias

NCT ID: NCT02733146 Completed - Hypothermia Clinical Trials

Histones and Free-plasma DNA After Cardiac Arrest

Start date: October 2015
Phase: N/A
Study type: Observational

To evaluate the significance of free-plasma deoxyribonucleic acid (DNA) and plasma histones in cardiac arrest patients.

NCT ID: NCT02731872 Completed - COPD Clinical Trials

The Effect of Oxygen Therapy With Airvo High-flow Heated Humidification

HHCOPD
Start date: January 2012
Phase: N/A
Study type: Interventional

The purpose of our study is to establish whether domiciliary use of the Airvo warm passover humidifier can reduce the number of exacerbations in patients with respiratory insufficiency. Participants must have a diagnosis of chronic obstructive pulmonary disease (COPD) and be in long term oxygen therapy (LTOT). The following questions will be investigated: Do outpatients receiving long term oxygen therapy benefit if this is delivered through an Airvo humidification system. The proposed benefits under investigation are: 1. a reduction in the number of exacerbations and thus hospital admissions? 2. an increase in quality of life (QOL)? 3. an improved lung function and thus increased physical activity?

NCT ID: NCT02730429 Completed - Endometrial Cancer Clinical Trials

Trial of Letrozole + Palbociclib/Placebo in Metastatic Endometrial Cancer

Start date: February 15, 2017
Phase: Phase 2
Study type: Interventional

This randomized double-blind, placebo-controlled phase 2 trial is evaluating superiority of Letrozole-palbociclib combination versus letrozole-placebo combination in ER positive endometrioid adenocarcinoma of endometrium

NCT ID: NCT02730416 Completed - Endometrial Cancer Clinical Trials

Combination Chemotherapy With Nintedanib / Placebo in Endometrial Cancer

Start date: December 12, 2016
Phase: Phase 2
Study type: Interventional

This study will evaluate the role of addition of an anti-angiogenic agent (Nintedanib/placebo) to conventional combination chemotherapy as concomitant and maintenance treatment in primary advanced or with first relapse of endometrial cancer.

NCT ID: NCT02728011 Completed - Clinical trials for Attention Deficit/Hyperactivity Disorder

Pilot Trial Comparing Computerised Cognitive Exercises to Tetris in Adolescents With ADHD

Start date: October 2010
Phase: N/A
Study type: Interventional

The purpose of this study was to examine the feasibility and efficacy of computerized cognitive exercises from Scientific Brain Training (SBT), compared to the computer game Tetris as an active placebo, in a pilot study of adolescents with Attention-deficit/hyperactivity disorder (ADHD).

NCT ID: NCT02727660 Completed - Clinical trials for Chronic Obstructive Pulmonary Disorder

A Study to Assess the Efficacy and Safety of PT009 Compared to PT005 on COPD Exacerbations Over a 52-Week Period in Subjects With Moderate to Very Severe COPD (Sophos)

Start date: April 29, 2016
Phase: Phase 3
Study type: Interventional

This is a Phase III randomized, double-blind, parallel group, multi-center, 52-week COPD exacerbation and lung function study with PT009 320/9.6 μg, PT009 160/9.6 μg and PT005 9.6 μg, all administered BID.

NCT ID: NCT02726581 Completed - Multiple Myeloma Clinical Trials

An Investigational Immuno-therapy Study of Nivolumab, Pomalidomide and Dexamethasone Combinations in Patients With Multiple Myeloma

CheckMate 602
Start date: August 10, 2016
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the safety and effectiveness of several combination therapies for Multiple Myeloma. Upon entry into the study, patients will be randomized (assigned by chance) to receive either: Group 1: nivolumab, pomalidomide and dexamethasone OR Group 2: pomalidomide and dexamethasone OR Group 3: nivolumab, elotuzumab, pomalidomide and dexamethasone. Enrollment is closed for all groups.