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NCT ID: NCT04831541 Recruiting - Prostate Cancer Clinical Trials

68Ga-PSMA-11 PET/CT in Patients With Various Types of Cancer

Start date: October 10, 2020
Phase: Early Phase 1
Study type: Interventional

To evaluate the potential usefulness of 68Ga-PSMA-11 positron emission tomography/computed tomography (PET/CT) for the diagnosis of primary and metastatic lesions, efficacy assessment and recurrence monitoring in various types of cancer.

NCT ID: NCT04831034 Recruiting - Fibrosis Clinical Trials

68Ga-FAPI PET/CT in Patients With Various Fibrotic Disease

Start date: April 1, 2021
Phase: Early Phase 1
Study type: Interventional

To evaluate the potential value of 68Ga-FAPI-04 positron emission tomography/ computed tomography (PET/CT) for the diagnosis and prognosis in fibrotic disease

NCT ID: NCT04830826 Recruiting - NSCLC, Stage III Clinical Trials

A Real-world Study of Adjuvant Therapy in Early Stage NSCLC With EGFR Mutation-Positive in China

Start date: June 10, 2020
Phase:
Study type: Observational

This study is a prospective, national, multi-center, non-interventional study. The main purpose is to explore the initial adjuvant treatment pattern after radical resection for early-stage NSCLC patients with EGFR Mutation-Positive in the real world. The secondary purpose was to observe the postoperative follow-up treatment pattern and its subgroups (based on different EGFR mutation status and different clinical stages).

NCT ID: NCT04830813 Recruiting - Clinical trials for Small Cell Lung Cancer

Phase 3 Clinical Study of Chiauranib Capsule in Patients With Small-cell Lung Cancer

Start date: March 5, 2021
Phase: Phase 3
Study type: Interventional

Chiauranib , which simultaneously targets against VEGFR/Aurora B/CSF-1R, several key kinases involved in tumor angiogenesis, tumor cell mitosis, and chronic inflammatory microenvironment.

NCT ID: NCT04830644 Recruiting - Clinical trials for Primary Sjögren Syndrome

A Study to Evaluate the Efficacy and Safety of Iguratimod Compared to Placebo in Patients With Active Primary Sjogren's Syndrome.

Start date: March 22, 2021
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of iguratimod compared to placebo in patients with active primary Sjogren's Syndrome.

NCT ID: NCT04830267 Recruiting - Clinical trials for Nasopharyngeal Carcinoma

The Efficacy of Camrelizumab Plus Stereotactic Body Radiotherapy in R/M NPC

Start date: March 1, 2021
Phase: Phase 2
Study type: Interventional

Camrelizumab is an antibody targeting programmed death receptor 1 (PD-1) and its ligand programmed death-ligand 1 (PD- L1) that is designed to boost the immune system. It does this by allowing immune cells to fight the cancer. Stereotactic body radiotherapy is a potential immunostimulatory therapy that may amplify antitumor response when combined with camrelizumab.

NCT ID: NCT04829708 Recruiting - Clinical trials for Limited Stage Small Cell Lung Cancer

Efficacy and Safety of Prophylactic Cranial Irradiation Versus MRI Surveillance in Patients With Limited-stage Small Cell Lung Cancer Who Achieved Remission After First-line Chemoradiotherapy

Start date: April 26, 2021
Phase: Phase 3
Study type: Interventional

This is a prospective, open,multicenter, randomized controlled phase III clinical trial. In patients with LS-SCLC who achieve remission after first-line chemoradiotherapy, the efficacy and safety of PCI or MRI surveillance is evaluated and analyzed. PCI is performed in hopes of preventing spread of cancer into the brain. The use of brain MRI alone may reduce side effects of receiving PCI and prolong patients' lifespan. MRI surveillance alone (delaying radiation until the actual brain metastasis) may be not inferior to PCI.

NCT ID: NCT04829409 Recruiting - Pain, Acute Clinical Trials

The Effects of Three Different Ultrasound-guided Nerve Blocks in VATS

Start date: April 5, 2021
Phase: N/A
Study type: Interventional

Ultrasound-guided mid-point transverse process to pleura block, erector spinae plane block and paravertebral block are three different methods of nerve block, used for relieving postoperative pain in thoracic anesthesia. This study is to compare them on block effects, postoperative pain and analgesic consumption in video-assisted thoracic surgery.

NCT ID: NCT04829097 Recruiting - Glioblastoma Clinical Trials

Neoadjuvant Temozolomide Combined With Simultaneous IMRT for Treatment of Glioblastoma

Start date: November 1, 2020
Phase: Phase 3
Study type: Interventional

This study is a prospective, multi-center, randomized controlled clinical study. Indications: Glioblastoma diagnosed after surgery (WHO grade IV). The patient received conventional postoperative concurrent radiotherapy and chemotherapy, or neoadjuvant temozolomide combined with concurrent increased intensity-modulated radiotherapy. According to data from previous clinical trials, conventional doses of concurrent radiotherapy and chemotherapy PFS 6.9 months neoadjuvant temozolomide combined with concurrently increased intensity-modulated radiotherapy PFS 13.7 months, an estimated 20% leakage rate, and a total sample size of 80 patients.

NCT ID: NCT04829019 Recruiting - Neurocognitive Clinical Trials

Neurocognition in NSCLC Patients Treated With Osimertinib or Osimertinib + WBI

Start date: April 7, 2021
Phase: Phase 2
Study type: Interventional

This is a prospective, randomised, positive-controlled, study to assess the neurocognitive function of upfront Osimertinib compared to whole-brain irradiation (WBI) plus Osimertinib in EGFR-mutant (Ex 19Del and L858R) NSCLC patients with symptomatic brain metastases, as well as the efficacy and safety.