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NCT ID: NCT05993858 Not yet recruiting - Clinical trials for Head and Neck Squamous Cell Carcinoma

Neoadjuvant PD-1 Inhibitor Combined With Cetuximab in Operable Locally Advanced HNSCC

PC-1
Start date: October 20, 2023
Phase: Phase 2
Study type: Interventional

This is a single-center, single-arm, phase II clinical study to evaluate the efficacy and safety of PD-1 inhibitor combined with cetuximab in neoadjuvant therapy for locally advanced HNSCC.

NCT ID: NCT05992168 Not yet recruiting - Clinical trials for PE - Pulmonary Thromboembolism

Stent-Retriever for Acute Massive Pulmonary Embolism (SRAME)

SRAME
Start date: December 15, 2023
Phase: N/A
Study type: Interventional

To evaluate treatment outcomes of patients diagnosed with pulmonary embolism.

NCT ID: NCT05991531 Not yet recruiting - Clinical trials for Chronic Hepatitis B Patients

Dynamic Changes of Serum HBV RNA in Chronic Hepatitis B Patients

Start date: August 15, 2023
Phase:
Study type: Observational

Some patients with low-level viremia (LLV) are also likely to develop hepatocellular carcinoma (HCC) or other liver diseases. The relationship between HBV RNA levels and fibrosis in patients with HBV DNA negative or LLV is still lacking evidence. The purpose of this study is to observe the differences in HBV RNA levels and their association with efficacy in HBV DNA negative or LLV patients. Investigators conduct the prospective, single-center, non-randomized, observational clinical study. A total of 100 chronic hepatitis B (CHB) patients who receive antiviral therapy with nucleoside (acid) analogues for 1-3 years will be enrolled. The enrolled patients will be followed up five times to collect clinical data and record adverse events (at baseline, week 12, week 24, week 36 and week 48, respectively).

NCT ID: NCT05991193 Not yet recruiting - NSCLC Clinical Trials

A Study With Central Nervous System Metastatic EGFR Mutation Positive Non-small Cell Lung Cancer

Start date: December 29, 2023
Phase:
Study type: Observational

This is a descriptive observational study, in which data are collected in an epidemiological fashion and prospective. This study does not intend to intervene the current medical practice of the recruited patients.

NCT ID: NCT05990985 Not yet recruiting - Clinical trials for Diffuse Large B-cell Lymphoma

The Efficacy and Safety of the RCMOP Sequential Therapy as a First-line Treatment for Patients With Intermediate-to-high Risk Diffuse Large B-cell Lymphoma Who Had Incomplete Remission.

Start date: September 1, 2023
Phase: N/A
Study type: Interventional

A clinical study was conducted to evaluate the efficacy and safety of the RCMOP regimen sequential therapy as a first-line treatment for patients with intermediate-to-high risk diffuse large B-cell lymphoma who had incomplete remission.

NCT ID: NCT05990127 Not yet recruiting - Clinical trials for Locally Advanced or Metastatic NSCLC

A Study of AK104/Tislelizumab With Chemotherapy as First-line Treatment in PD-L1 TPS < 1% Non-small Cell Lung Cancer

Start date: November 14, 2023
Phase: Phase 3
Study type: Interventional

This is a randomized, double-blind, phase III clinical study to compare the efficacy and safety of AK104 combined chemotherapy versus Tislelizumab combined chemotherapy in first-line treatment of Locally advanced or metastatic NSCLC with PD-L1 TPS < 1%.

NCT ID: NCT05988372 Not yet recruiting - Clinical trials for Locally Advanced Pancreatic Cancer

Surufatinib and Serplulimab Combined With AG Regimen Compare With AG Regimen as Conversion Therapy for Patients With Locally Advanced Pancreatic Cancer (SAGE)

Start date: October 23, 2023
Phase: Phase 2
Study type: Interventional

This is a Phase II Randomized Controlled PILOT clinical study. The purpose of this study is to explore the efficacy and safety of surufatinib and serplulimab in combination with albumin-paclitaxel and gemcitabine in the conversion therapy for patients with unresectable locally advanced pancreatic cancer. Furthermore, it compares the efficacy of surufatinib and serplulimab in combination with albumin-paclitaxel and gemcitabine to the albumin-paclitaxel and gemcitabine regimen in the conversion therapy for patients with unresectable locally advanced pancreatic cancer.

NCT ID: NCT05988177 Not yet recruiting - Clinical trials for Hemophagocytic Lymphohistiocytoses

Efficacy and Safety of Carrimycin Tablets in HLH Patients With Carbapenem-resistant Infections

Start date: August 30, 2023
Phase: N/A
Study type: Interventional

This study aimed to investigate the efficacy and safety of Carrimycin tablets in hemophagocytic lymphohistiocytosis patients with Carbapenem-resistant infections.

NCT ID: NCT05987696 Not yet recruiting - Clinical trials for Minimal Residual Disease

Natural Killer(NK) Cell Therapy in Acute Myeloid Leukemia

Start date: August 10, 2023
Phase: Phase 1
Study type: Interventional

This is a phase 1, first-in-human (FIH), open-label, multicohort study to evaluate the safety, tolerability and preliminary efficacy of iPSC NK cells in patients with relapsed/refractory AML or AML Minimal Residual Disease (MRD).

NCT ID: NCT05987605 Not yet recruiting - Clinical trials for Advanced Malignancies

Clinical Study of 1A46 Drug Substance

Start date: October 1, 2023
Phase: Phase 1
Study type: Interventional

A phase I/II, first in human, single arm, open label study to evaluate the safety and efficacy of the injection of triple-specific T-cell engager 1A46 in adult subjects with R/R CD20 positive and/or CD19 positive B cell non-Hodgkin's lymphoma (B - NHL)