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NCT ID: NCT05624164 Recruiting - Rotator Cuff Tears Clinical Trials

Microfracture at Proximal Humerus Lateral to Footprint Could Enhance the Rotator Cuff Healing

Start date: October 1, 2022
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to test whether there is any effect on rotator cuff healing by making microfracture at the lateral side of the footprint. The main question it aims to answer are: - [whether the lateralized microfracture could decrease the retear rate after arthroscopy rotator cuff repair.] - [whether the lateralized microfracture could improve the functional recovery after arthroscopy rotator cuff repair.] Participants with medium to larger size rotator cuff tears will be randomly assigned to the study group treated with lateralized microfracture immediately after arthroscopy rotator cuff repair or the control group treated with conventional arthroscopy rotator cuff repair without microfracture.

NCT ID: NCT05624112 Completed - Atopic Dermatitis Clinical Trials

Dupilumab Skin BArrier Function and LIpidomics STudy in Atopic Dermatitis in China

BALISTAD-CN
Start date: November 25, 2022
Phase: Phase 4
Study type: Interventional

This is a 16-week, open label, exploratory study designed to investigate dupilumab's effect on skin barrier function as measured by transepidermal water loss (TEWL) before and after skin tape stripping. During the first 2 treatment weeks, patients will have 2 on-site visits/week, followed by one on-site visit/week up to Week 4, one on-site visit every two weeks from Week 4 to Week 8, and one on-site visit every 4 weeks up to Week 16 End of Treatment phase visit (EoT) thereafter. A follow-up visit by phone 4 weeks after the last study assessment at Week 16 will end the study for each participant (End of Study: EoS). The maximum duration of the study per participant will be 24 weeks.

NCT ID: NCT05624099 Recruiting - Clinical trials for Esophageal Neoplasms

Camrelizumab Combined With Chemoradiotherapy in Advanced Esophageal Cancer.

Start date: August 1, 2023
Phase: Phase 2
Study type: Interventional

This is a prospective single-arm exploratory clinical study. The efficacy and safety of camrelizumab combined with chemoradiotherapy and camrelizumab combined with chemotherapy were evaluated in patients with advanced esophageal cancer who had not previously received any systemic antitumor therapy for esophageal cancer.

NCT ID: NCT05623995 Recruiting - In-stent Restenosis Clinical Trials

Effect of Evolocumab on Chronic Total Occlusions (EVOLO-CTO)

Start date: December 15, 2022
Phase: Phase 4
Study type: Interventional

The purpose of this study is to evaluate the effect of proprotein convertase subtilisin/kexin type-9 (PCSK9) inhibitors added to regular statin therapy on target lesion failure (TLF) and arteriosclerosis progression in patients with chronic total occlusions (CTOs) undergoing successful percutaneous coronary intervention (PCI).

NCT ID: NCT05623982 Recruiting - Clinical trials for Non-hodgkin's Lymphoma

Phase Ib/II Study of GNC-038 Injection in Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma

Start date: September 26, 2022
Phase: Phase 1/Phase 2
Study type: Interventional

To explore the safety and preliminary efficacy of GNC-038 in patients with relapsed or refractory NHL, and to determine the MTD and RP2D of GNC-038, or the MAD and DLT

NCT ID: NCT05623943 Completed - Stroke, Ischemic Clinical Trials

Comparison of Cerebral Artery Pressure Gradient and Cerebral Blood Flow Measured by Arterial Spin Labeling

Start date: June 1, 2019
Phase:
Study type: Observational

The goal of this observational study is to explore the ability of intravascular pressure gradients to identify hemodynamic disturbance in patients with intracranial atherosclerotic diseases (ICAS). The main questions that aim to answer are: - The correlation between intravascular pressure gradient and cerebral blood flow (CBF) - The threshold for intravascular pressure gradients to predict hemodynamic disturbance in ICAS Patients will undergo intravascular pressure measurement and arterial spin labeling (ASL) for CBF during pre- and post-operation respectively.

NCT ID: NCT05623904 Recruiting - Clinical trials for Carotid Endarterectomy

Carotid Revascularization Versus Best Medical Treatment for Asymptomatic Carotid Stenosis

Start date: October 14, 2022
Phase: N/A
Study type: Interventional

This is a multicenter, open, randomized controlled trial to evaluate the efficacy and safety of carotid artery stenting/carotid endarterectomy versus best medical treatment for asymptomatic carotid artery stenosis in Chinese population.

NCT ID: NCT05623891 Not yet recruiting - Solid Tumor, Adult Clinical Trials

Safety Study of 177Lu-Anti-ED-B mAbs SPECT Imaging in Patients With ED-B Positive Solid Tumors

Start date: December 2022
Phase: Early Phase 1
Study type: Interventional

This is a single arm study to evaluate the safety and biodistribution of 177Lu-labeled anti-ED-B mAbs SPECT imaging in patients with ED-B positive solid tumors.

NCT ID: NCT05623878 Recruiting - Prostatic Cancer Clinical Trials

68Ga-labeled NY108 PET Imaging in Patients

Start date: January 4, 2022
Phase: Early Phase 1
Study type: Interventional

This is a single arm study to evaluate the safety and biodistribution of 68Ga-labeled NY108 (68Ga-NY108) PET Imaging in patients.

NCT ID: NCT05623722 Recruiting - Sepsis Clinical Trials

Erector Spinae Plane Block Improves Organ Dysfunction in Septic Patients With Acute Gastrointestinal Injury

Start date: December 29, 2022
Phase: N/A
Study type: Interventional

This study is a prospective, multicenter, parallel-group, open-label, randomized controlled clinical trial. Sepsis is defined as organ dysfunction induced by infections. And sepsis and gastrointestinal injury can be the leading cause for each other. Our previous study showed erector spinae plane block improved the organ dysfunctions in patients with AGI. The aim of the clinical trial is to investigate erector pinae plane block improves the organ dysfunction in septic patients with acute gastrointestinal injury.