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NCT ID: NCT05673590 Recruiting - Clinical trials for Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Utidelone Versus Docetaxel in Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Start date: May 12, 2023
Phase: Phase 3
Study type: Interventional

The purpose of this clinical trial is to compare Utidelone with Docetaxel in patients with locally advanced or metastatic non-small cell lung cancer previously failed platinum-containing chemotherapy regimens. This phase III, open-label, randomized controlled trial aims to evaluate and compare the efficacy and safety of Utidelone and Docetaxel in the aforementioned lung cancers.

NCT ID: NCT05673577 Recruiting - Clinical trials for Squamous Cell Carcinoma of Head and Neck

Camrelizumab in Combination With Cetuximab and Chemotherapy for Relapsed/Metastatic HNSCC Patients

Start date: March 22, 2023
Phase: Phase 2
Study type: Interventional

This is a single-center, single-arm, phase 2 study to evaluate the efficacy and safety of camrelizumab in combination with cetuximab and chemotherapy as first-line for patients with relapsed/metastastic head and neck squamous cell carcinoma

NCT ID: NCT05673538 Not yet recruiting - Clinical trials for Advanced Solid Tumor

TT-00973-MS Tablets in Patients With Advanced Solid Tumors

Start date: January 2023
Phase: Phase 1
Study type: Interventional

This study is a multicenter, open-label, phase 1 study to evaluate the safety, tolerability, pharmacokinetics and preliminary efficacy of TT-00973-MS tablets in patients with solid tumors.

NCT ID: NCT05673525 Not yet recruiting - Aortic Stenosis Clinical Trials

A Clinical Trial of the Transcatheter Aortic Valve Implantation System With a Prospective, Multi-Center, One-Arm Approach to Evaluate the Efficacy and Safety in the Treatment of Patients With Severe Aortic Stenosis

Start date: December 30, 2022
Phase: N/A
Study type: Interventional

A Clinical Trial of the Transcatheter Aortic Valve Implantation System with a Prospective, Multi-Center, One-Arm Approach to Evaluate the Efficacy and Safety in the Treatment of Patients with Severe Aortic Stenosis

NCT ID: NCT05673512 Recruiting - HER2 Gene Mutation Clinical Trials

To Evaluate IAH0968 in Combination With CAPEOX in HER2-positive Metastatic Colorectal Cancer

Start date: May 12, 2023
Phase: Phase 2/Phase 3
Study type: Interventional

The Phase IIa of this clinical study, a dose-escalation study of IAH0968 in combination with CAPEOX, is designed for safety and tolerability in subjects with HER2-positive advanced or metastatic solid tumors. Phase IIb/III is an operational seamless adaptive design consisting of two phases. Phase I (Phase IIb) was designed to initially evaluate the efficacy and safety of IAH0968+CAPEOX in HER2-positive subjects with metastatic colorectal cancer, using PFS.

NCT ID: NCT05673499 Recruiting - Clinical trials for Congenital Disorders

International Study of Cerebral Oxygenation and Electrical Activity During Major Neonatal Surgery

Start date: August 12, 2022
Phase:
Study type: Observational

The goal of this observational study is to determine the incidence of perioperative cerebral desaturation in neonates undergoing surgery for congenital malformations. The main questions it aims to answer are: 1. The perioperative factors associated with occurrence of cerebral desaturation 2. The association between perioperative cerebral desaturation, perioperative/hospital outcomes, and physiological conditions. Participants will undergo Near-infrared spectroscopy (NIRS) and electroencephalogram (EEG) monitoring for one hour before surgery, during surgery, and up to 24 hours after surgery.

NCT ID: NCT05673447 Recruiting - Clinical trials for Diffuse Large B Cell Lymphoma

The Study of Anti-CD19 CAR NK Cells in the Treatment of Relapsed/Refractory Diffuse Large B Cell Lymphoma

Start date: March 1, 2023
Phase: Early Phase 1
Study type: Interventional

A single arm, open-label pilot study is designed to determine the safety and effectiveness of anti-CD19 CAR NK cells in patients with B-cell Non Hodgkin Lymphoma. 9-12 patients are planned to be enrolled in the dose-escalation trial (6×10^8 cells, 1×10^9 cells, 1.5×10^9 cells). The primary endpoints are DLT, MTD. The secondary endpoints are the overall response rates (ORR) and disease control rate (DCR).

NCT ID: NCT05673109 Terminated - Clinical trials for Metastatic Castration Resistant Prostate Cancer

A Study of AC176 for the Treatment of Metastatic Castration Resistant Prostate Cancer

Start date: February 22, 2023
Phase: Phase 1
Study type: Interventional

This clinical trial is evaluating a drug called AC176 in Chinese participants with metastatic castration resistant prostate cancer (mCRPC) who have progressed on at least one prior systemic therapy. The main goals of this study are to: Evaluate the safety and tolerability of AC176, evaluate pharmacokinetics and preliminary antitumor activity of AC176

NCT ID: NCT05672888 Not yet recruiting - COVID-19 Pneumonia Clinical Trials

Efficacy and Safety of Jaktinib in Patients With COVID-19 Pneumonia.

Start date: March 2023
Phase: Phase 2
Study type: Interventional

This was a randomized, double-blind, placebo-controlled parallel study.

NCT ID: NCT05672693 Recruiting - Clinical trials for the Accuracy of Intraocular Lens Calculation Formula

Study on the Accuracy of Intraocular Lens Calculation Formula

Start date: January 2023
Phase:
Study type: Observational

In this study, we will retrospectively collect patients who have performed phacoemulsification combined with intraocular lens implantation in our hospital, collect various preoperative biometric data and postoperative refractive data of patients, conduct statistical analysis, and compare the accuracy of various IOL calculation formulas.