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NCT ID: NCT05689840 Completed - COVID-19 Clinical Trials

Association Between Post-covid Infection Status and Perioperative Morbidity: A Ambispective Cohort Study

Start date: December 1, 2022
Phase:
Study type: Observational [Patient Registry]

With the knowledge of currently transmitted omicron variant being less virulent, over 90 percent of the Chinese population is fully vaccinated, and the Chinese health workers have sufficient experience treating the illness. China 's epidemic prevention and control has entered a new stage to restore the normal functioning of society and basic medical services, On Dec, 7, China released a circular on further optimizing its COVID-19 response, announcing 10 new prevention and control measures.This has marked the watershed for sharply increased number of elective surgical patients diagnosed with COVID-19 during preoperativley, fully recovered or during recovery. Beijing faced a wave of omicron infection starting that would result in of a wide range of population infections. At which time there is limited evidence regarding the optimal timing of surgery following SARS-CoV-2 infection especially for omiron among Chinsese patients .This study intends to explore the relationship between the incidence of postoperative complications after elective surgery and COVID-19 infection in Peking Union Medical College Hospital, and provide data support for the policy formulation of elective surgical timing for patients after COVID-19 infection.

NCT ID: NCT05689645 Recruiting - Clinical trials for Acute-On-Chronic Liver Failure

F573 for Injection for the Treatment of Liver Injury/Failure

Start date: March 24, 2023
Phase: Phase 2
Study type: Interventional

This study was a randomized, double-blind, placebo-controlled Phaseâ…¡ clinical trial . The primary objective of this study was to evaluate the safety of F573 for injection in patients with liver injury (drug-induced liver injury (DILI), chronic hepatitis B (CHB), etc.).

NCT ID: NCT05689567 Active, not recruiting - Myopia Clinical Trials

Focus-out Glasses on Emmetropization in Chinese Children

Start date: March 23, 2023
Phase: N/A
Study type: Interventional

The purpose of this study is to characterize the effects of peripheral focous-out glasses on emmetropization in non-myopic Chinese Children Aged 6-8 Years.This is a prospective, parallel-controlled randomized trial.

NCT ID: NCT05689528 Completed - Clinical trials for Acute Ischemic Stroke

The Screening of Neuroprotective Biomarkers After Acute Ischemic Stroke

Start date: July 1, 2017
Phase:
Study type: Observational

Neuroprotection is expected to be an important therapeutic strategy for acute ischemic stroke(AIS), but almost all neuroprotective drugs proved effective in rodent models have failed after entering clinical trials. This study aims to screen the differentially expressed proteins in peripheral blood of patients with acute ischemic stroke and with further study in the animal model of non-human primate cerebral infarction, we may determine the biomarkers that can evaluate the efficacy of neuroprotective drugs.

NCT ID: NCT05689216 Not yet recruiting - Clinical trials for Corona Virus Infection

Timed Awake Prone and Repositioning for Patients With Covid-19-induced Hypoxic Respiratory Failure.

Start date: January 18, 2023
Phase: N/A
Study type: Interventional

Awake prone positioning has been reported to improve oxygenation for patients with COVID-19. Awake timed and repositioning is a novel method to improve patients' compliance and prolong the prone time. This study aims to explore the impact of timed prone and repositioning on the intubation rate and prognosis of COVID-19 patients with hypoxic respiratory failure.

NCT ID: NCT05689203 Recruiting - COVID-19 Clinical Trials

A Phase 2 Study to Evaluate the Efficacy and Safety of QLS1128 Orally in Symptomatic Participants With Mild to Moderate COVID-19

Start date: December 30, 2022
Phase: Phase 2
Study type: Interventional

A Phase 2 Study to Evaluate the Efficacy and Safety of QLS1128 Orally in Symptomatic Participants With Mild to Moderate COVID-19

NCT ID: NCT05689138 Active, not recruiting - Pancreatic Cancer Clinical Trials

Using Digestive Microbial Information to Enhance the Early Detection of Pancreatic Cancer

Start date: September 1, 2020
Phase:
Study type: Observational

Pancreatic cancer (PCA) is a leading death-related cancer. There is an urgent need for accurate, noninvasive diagnostic options in the early detection of pancreatic cancer (PCA), since delayed diagnosis increases the risk of metastasis and recurrence. In this study, by analyzing gut and fecal microbial data among the pancreatic versus healthy populations, we aim to establish an early detection tool to improve PCA detection, and to explore potential diagnostic biomarkers.

NCT ID: NCT05689125 Completed - Clinical trials for Endotracheal Intubation

Bougies as Aid for Endotracheal Intubation Via Video Laryngoscopy During Continuous Chest Compressions

Start date: February 9, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical trials is to analyze the effects of using bougies as adjuncts on the performance of endotracheal intubation via video laryngoscopy during cardiopulmonary resuscitation in anesthesia residents. The main question it aims to answer is whether bougie use has a significant effect on first-attempt failure of endotracheal intubation via video laryngoscopy during continuous chest compressions. Participants will perform endotracheal intubation via video laryngoscopy by four methods in a randomized order in a simulated cardiopulmonary resuscitation scenario on a manikin. The four methods are endotracheal intubations assisted by a railroaded bougie, assisted by a preloaded bougie, assisted by a stylet, and with no assistance. Researchers will compare the first-attempt failure rate of the four methods to see if a railroaded bougie method has a significant different first-attempt failure from that of the other three methods.

NCT ID: NCT05689073 Completed - Clinical trials for Vaccination Hesitancy

A Conversational AI System to Enhance Knowledge About Vaccines and Promote Vaccination

Start date: May 1, 2023
Phase: N/A
Study type: Interventional

This study is designed to contribute to the growing body of evidence on the efficacy of digital health interventions. By rigorously evaluating the impact of the AI system on vaccine knowledge and acceptance, the study aims to inform future health communication strategies and policies. It stands as a potential model for integrating AI into public health initiatives, showcasing how technology can be harnessed to improve health outcomes on a large scale.

NCT ID: NCT05689008 Recruiting - COVID-19 Pneumonia Clinical Trials

UC-MSCs in the Treatment of Severe and Critical COVID-19 Patients With Refractory Hypoxia

Start date: January 10, 2023
Phase: Phase 3
Study type: Interventional

The goal of this randomized, controlled, open-labeled interventional clinical trial is to test the efficacy and safety of umbilical cord mesenchymal stem cells (UC- MSCs) in the treatment of severe and critical COVID-19 patients with refractory hypoxia even after sufficient standard treatment according to the tenth edition of Chinese guidelines for COVID-19 infection. The main questions it aims to answer are: 1. The efficacy of UC-MSCs in the treatment of severe and critical COVID-19 patients with refractory hypoxia. 2. The safety of UC-MSCs in the treatment of severe and critical COVID-19 patients. 3. The potential immune mechanisms of UC- MSCs in the treatment of severe and critical COVID-19 patients. Participants will receive standard therapy, or the UC-MSCs treatment. For the standard treatment, it will be conducted according the 10th edition of Chinese guidelines for severe or critical COVID-19 infection. For UC-MSCs treatment, participants will be given UC-MSCs instillation at the first and fourth day after assignment. Blood examples will be taken at indicated time for arterial blood gas analysis and other tests. And participants should also objectively report their symptoms change and other information related to the treatment as listed the research protocol.