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NCT ID: NCT05911984 Not yet recruiting - Clinical trials for Advanced Malignant Solid Tumor

A Study to Evaluate the Safety, Tolerability, Pharmacokinetic Properties and Preliminary Efficacy of 9MW3811 in Patients With Advanced Solid Tumors

Start date: June 30, 2023
Phase: Phase 1
Study type: Interventional

This is a single ascending dose study of 9MW3811, the primary objective of which is to evaluate the safety, tolerability and preliminary efficacy of 9MW3811 in patients with advanced solid tumors.

NCT ID: NCT05911958 Recruiting - Clinical trials for HER2 Low Breast Carcinoma

A Study of SHR-A1811 as Neoadjuvant Treatment for Patients With HR-Positive, Low HER2 Expression Breast Cancer

Start date: July 5, 2023
Phase: Phase 2
Study type: Interventional

HR-positive breast cancers accounts for about 50% to 60% of all breast cancer patients. Neoadjuvant Chemotherapy is the core treatment mode for this type of breast cancer, and endocrine therapy can be used in some low-risk patients. However, the pathological complete response (pCR) rate obtained is low. HER2 is an important prognostic indicator and therapeutic target for breast cancer. Nearly 60% of HR-positive breast cancers have low expression of HER2, and antibody-drug conjugates (ADC) targeting HER2 may achieve better efficacy in this subtype.

NCT ID: NCT05911893 Not yet recruiting - Undernutrition Clinical Trials

the Effect of High Caloric Oral Nutritional Supplements on Growth and Development of Malnourished Children

EHCONSGDMC
Start date: June 30, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to investigate the effect of high caloric oral nutritional supplements on body proportion, weight, linear growth pattern, neuropsychological development level and related health aspects (gut health, immune function, quality of life, etc.) in participants aged 1 to 3 years who are malnourished (underweight and wasting),as well as to evaluate the safety of applying high caloric oral nutritional supplements. Participants will receive nutritional education and daily high caloric oral nutritional supplements(experimental group),or will receive nutritional education and dietary instruction(control group).This study may provide data to support the development of clinical intervention strategies for malnourished Chinese children.

NCT ID: NCT05911841 Recruiting - Atopic Dermatitis Clinical Trials

A Study of LY3454738 in the Treatment of Adult Participants With Moderate-to-Severe Atopic Dermatitis

Start date: June 21, 2023
Phase: Phase 2
Study type: Interventional

The main purpose of this study is to describe the efficacy and safety of LY3454738 in adult participants with moderate-to-severe atopic dermatitis (AD).

NCT ID: NCT05911685 Active, not recruiting - Atrial Fibrillation Clinical Trials

Evaluation of the Safety and Efficacy of a Novel SeaLA™ Left Atrial Appendage Occluder

Start date: March 26, 2019
Phase: N/A
Study type: Interventional

This study adapted a prospective, multicenter single-group objective performance criteria design. A total of 163 patients with non-valvular atrial fibrillation were enrolled in the clinical trial,follow up were scheduled in 7 days, 45 days, 6 months, 12 months, 2 years, 3 years, 4 years and 5years after procedure.

NCT ID: NCT05911503 Recruiting - Clinical trials for Cytomegalovirus Retinitis

Clinical Study of High Concentration Ganciclovir Eye Drops in the Treatment of Cytomegalovirus Retinitis

Start date: July 1, 2023
Phase: Early Phase 1
Study type: Interventional

Clinical study of high concentration ganciclovir eye drops in the treatment of cytomegalovirus retinitis

NCT ID: NCT05911464 Recruiting - Clinical trials for Advanced Solid Tumor

A Phase I Study of HS-10386 in Participants With Advanced Solid Tumors

Start date: March 2, 2023
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the safety and tolerability, pharmacokinetics, and preliminary anti-tumor activity of HS-10386 in participants with advanced solid tumors who have failed prior treatments.

NCT ID: NCT05911438 Not yet recruiting - Clinical trials for Total Knee Arthroplasty

Accelerated Recovery for Total Knee Replacement Surgery With Preoperative Intravenous Iron Combined With Human Erythropoietin for Rapid Hematopoietic Mobilization to Prevent Postoperative Anemia

Hematoboost
Start date: July 2023
Phase: N/A
Study type: Interventional

This study is a randomized, placebo-controlled, multicenter research design to investigate the effectiveness and safety of a single-dose intravenous iron combined with HuEPO hematopoietic mobilization before surgery in patients undergoing unilateral total knee arthroplasty for the first time.

NCT ID: NCT05911217 Recruiting - Pancreatic Cancer Clinical Trials

A Study to Evaluate the Efficacy and Safety of CT041 After Adjuvant Chemotherapy for Pancreatic Cancer

Start date: July 11, 2023
Phase: Phase 1
Study type: Interventional

An open-label, single-arm, multicenter, Phase Ib clinical trial to evaluate the efficacy and safety of CT041 Autologous CAR T Cell Injection after adjuvant chemotherapy in subjects with pancreatic cancer.

NCT ID: NCT05911152 Recruiting - Colorectal Cancer Clinical Trials

Safety and Feasibility of Laparoscopic Intracorporeal Anastomosis for Colorectal Surgery- A Multiple Center Real World Study

SELECTED
Start date: January 1, 2016
Phase:
Study type: Observational

The goal of this observational study is to explore the safety and feasibility of laparoscopic intracorporeal anastomosis in colorectal cancer surgery. The main questions it aims to answer are: 1. If intracorporeal anastomosis is safe in terms of short-term outcome? 2. If intracorporeal anastomosis can achieve the same oncological outcome as conventional extracorporeal anastomosis?