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NCT ID: NCT05957536 Recruiting - Clinical trials for HER-2 Positive Advanced Solid Tumors

A Study of D3L-001 as Monotherapy in Subjects With HER2-Positive Advanced Solid Tumors

Start date: September 19, 2023
Phase: Phase 1
Study type: Interventional

This first-in-human (FIH) study, multi-center, open-label, dose escalation and dose expansion Phase I study to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), immunogenicity, and preliminary anti-tumor activity of D3L-001 in subjects with HER2-positive advanced solid tumors.

NCT ID: NCT05957523 Not yet recruiting - Clinical trials for Ischemic Preconditioning

Effects of Remote Ischemic Preconditioning on Components of Peripheral Blood and Gut Microbiome (EMINENT)

EMINENT
Start date: May 20, 2024
Phase: N/A
Study type: Interventional

The aim of this study is to investigate the effects of remote ischaemic preconditioning on the peripheral blood characteristics of healthy adults and to explore the possible mechanisms for improving ischaemia/reperfusion injury and its protective effects on the cardiovascular system.

NCT ID: NCT05957510 Recruiting - Clinical trials for Small-cell Lung Cancer

Safety and Efficacy Evaluation of Serplulimab Plus Chemo in SCLC Transformed From EGFR-mutated NSCLC After Treatment

Start date: July 10, 2023
Phase: Phase 2
Study type: Interventional

This investigator-initiated, open-label, prospective Phase II clinical trial, planned to take place across multiple centers in China. We design this trial to evaluate the safety and efficacy of Serplulimab plus chemotherapy in SCLC transformed from EGFR-mutated NSCLC after treatment.

NCT ID: NCT05957471 Recruiting - Clinical trials for Locally Advanced or Metastatic Solid Tumors

Study of BC3195 Monotherapy in Patients With Advanced Solid Tumors

BC3195
Start date: June 26, 2023
Phase: Phase 1
Study type: Interventional

This is a phase I study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Preliminary Efficacy of BC3195 in Patients with Locally Advanced or Metastatic Solid Tumors.

NCT ID: NCT05957458 Completed - Myopia Clinical Trials

Myopia Control With Three Lever Irradiance of PBM Therapy in Children and Adults

MCPT
Start date: January 1, 2021
Phase: N/A
Study type: Interventional

Photobiomodulation therapy, that is, Low-level red-light technology provides a new and innovative myopia control approach. This strategy enables relatively high energies of light to be delivered at much shorter durations of exposure to induce the myopia control effect. The efficacy of the low-level red-light technology has been proven in a Chinese populationb for the recent 3 years with evidence based papers and amazing results. However, there's not yet evidence to demonstrate the relationship between the dose response effect of photobiomodulation therapy on myopia control at the different age lever.

NCT ID: NCT05957445 Recruiting - Stroke Clinical Trials

pBFS-guided Multi-target cTBS for Aphasia After Stroke

Start date: August 23, 2023
Phase: N/A
Study type: Interventional

In this study, a randomized, double-blind, parallel-controlled trial was employed to evaluate the effectiveness and safety of personalized brain functional sectors (pBFS) technology-guided continuous theta burst stimulation (cTBS) on the inferior frontal gyrus (IFG) combined with the superior temporal gyrus (STG) and the superior frontal gyrus (SFG) for language function recovery in post-stroke aphasic patients.

NCT ID: NCT05957419 Recruiting - Clinical trials for Hypertrophic Obstructive Cardiomyopathy

Transapical Beating-Heart Septal Myectomy in Patient With Hypertrophic Obstructive Cardiomyopathy: a Multi-Center Study

Start date: July 2023
Phase: N/A
Study type: Interventional

The primary purpose of this study is to evaluate the feasibility, the safety and the efficacy of the transapical beating-heart septal myectomy for the treatment of hypertrophic obstructive cardiomyopathy. This is a prospective, single-arm, multi-center study.

NCT ID: NCT05957354 Recruiting - Stroke Clinical Trials

pBFS-guided Dual-target cTBS for Aphasia After Stroke

Start date: July 28, 2023
Phase: N/A
Study type: Interventional

The objective of this trial is to evaluate the effectiveness and safeness of personalized brain functional sectors (pBFS) technology-guided continuous theta burst stimulation (cTBS) on the inferior frontal gyrus (IFG) combined with the superior temporal gyrus (STG) for language function recovery in post-stroke aphasic patients.

NCT ID: NCT05957107 Completed - Clinical trials for Rheumatoid Arthritis

Phase II Trial of VDJ001 in Patients With Moderate-to-severe Active Rheumatoid Arthritis

Start date: May 26, 2022
Phase: Phase 2
Study type: Interventional

This is a multicenter, randomized, double-blind, placebo and tocilizumab controlled phase II trial in RA patients to evaluate the initial efficacy, safety, pharmacokinetic, pharmacodynamic characteristics, and immunogenicity of VDJ001 in RA patients.

NCT ID: NCT05957016 Recruiting - Rectal Cancer Clinical Trials

Neoadjuvant CIETAI With Concurrent Chemoradiotherapy in Local Advanced Rectal Cancer

Start date: August 30, 2023
Phase: Phase 2
Study type: Interventional

To increase the efficacy of neoadjuvant PD-1/PD-1 checkpoint inhibitor in local advanced rectal cancer (LARC), we propose preoperative arterial infusion of Tirellizumab and oxaliplatin followed by tumor artery embolization with concurrent chemoradiotherapy as neoadjuvant regimen for LARC.