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NCT ID: NCT05879627 Recruiting - Clinical trials for Advanced Solid Tumors

To Evaluate the Safety, Tolerance and Pharmacokinetics of BAT8007 for Injection in Patients With Advanced Solid Tumors

Start date: January 17, 2023
Phase: Phase 1
Study type: Interventional

A multicenter, open phase I clinical study to evaluate the safety, tolerance and pharmacokinetics of BAT8007 for injection in patients with advanced solid tumors.

NCT ID: NCT05879523 Recruiting - Clinical trials for Obstructive Hypertrophic Cardiomyopathy

A Trial of HRS-1893 in Healthy Volunteers and Patients With Obstructive Hypertrophic Cardiomyopathy

Start date: June 5, 2023
Phase: Phase 1
Study type: Interventional

The purpose of this phase Ⅰ study is to evaluate the safety, tolerability and pharmacokinetics of HRS-1893 in healthy volunteers and patients with obstructive hypertrophic cardiomyopathy

NCT ID: NCT05879510 Recruiting - Clinical trials for Clear Cell Renal Cell Carcinoma

68Ga-NY104 PET/CT for the Detection of Clear Cell Renal Cell Carcinoma in Presurgical Patients With Renal Masses

Start date: August 1, 2023
Phase: Phase 2
Study type: Interventional

This is a prospective, single-center, single-arm, diagnostic phase 2 study in patients who have renal masses scheduled for surgical resection. The goal is to determine the sensitivity and specificity of 68Ga-NY104 PET/CT in the detection of clear cell renal cell carcinoma using histopathological diagnosis as ground truth, in patients with operable renal masses.

NCT ID: NCT05879497 Recruiting - Clinical trials for Clear Cell Renal Cell Carcinoma

68Ga-NY104 PET/CT in Patients With Metastasis/Recurrence Clear Cell Renal Cell Carcinoma Suspicion

Start date: August 1, 2023
Phase: Phase 2
Study type: Interventional

This is a prospective, single-center, single-arm phase 2 study in patients with clear cell renal cell carcinoma and metastasis or recurrence suspicion. The goal is to determine the sensitivity and specificity of 68Ga-NY104 PET/CT in patients with clear cell renal cell carcinoma and metastasis or recurrence suspicion

NCT ID: NCT05879471 Recruiting - Clinical trials for Metastatic Clear Cell Renal Cell Carcinoma

68Ga-NY104 PET/CT in Patients With Metastatic Clear Cell Renal Cell Carcinoma

Start date: August 1, 2023
Phase: Phase 2
Study type: Interventional

This is a prospective, single-center, single-arm, comparative phase 2 study in patients with metastatic clear cell renal cell carcinoma. The goal is to determine the sensitivity of 68Ga-NY104 PET/CT in patients with metastatic clear cell renal cell carcinoma and compare it with 18F-FDG PET/CT.

NCT ID: NCT05879068 Recruiting - SCLC Clinical Trials

A Study of PM8002 in Combination With Chemotherapy in Patients With SCLC

Start date: May 27, 2022
Phase: Phase 2
Study type: Interventional

PM8002 is a bispecific antibody targeting PD-L1 and VEGF. This study will evaluate the efficacy and safety of PM8002 in combination with paclitaxel as second line treatment for SCLC.

NCT ID: NCT05879055 Recruiting - Clinical trials for Neuroendocrine Neoplasm

A Study of PM8002 Injection in Combination With Chemotherapy in Patients With NEN

Start date: May 17, 2023
Phase: Phase 2
Study type: Interventional

PM8002 is a bispecific antibody targeting PD-L1 and VEGF. This study will evaluate the efficacy and safety of PM8002 in combination with FOLFIRI as second line treatment for neuroendocrine neoplasm (NEC and Ki-67≥55% G3 NET).

NCT ID: NCT05879029 Recruiting - Clinical trials for Laryngopharyngeal Reflux

Clinical Study of Jinsang Liyan Capsules Combined With PPI in the Treatment of LPRD

Start date: July 1, 2023
Phase: Phase 4
Study type: Interventional

The goal of this clinical trial is to compare the efficacy of Jinsang Liyan capsule in combination with PPI versus PPI alone for the treatment of Laryngopharyngeal Reflux Disease (LPRD). Participants will be randomly assigned in a 1:1 ratio to the experimental group or the control group. The experimental group was treated with Jinsangliyan capsule + rabeprazole enteric-coated tablets, and the control group was treated with Jinsangliyan capsule placebo + rabeprazole enteric-coated tablets. Participants were followed up at 4 weeks and 8 weeks after taking the drug to evaluate the improvement of LPRD symptoms. Researchers will compare Experimental group and control group to see if Jinsang Liyan capsule combined with PPI treatment is superior to PPI treatment alone.

NCT ID: NCT05878717 Recruiting - Clinical trials for Scleroderma, Systemic

A Study of the Efficacy and Safety of Belimumab in Adults With Systemic Sclerosis Associated Interstitial Lung Disease

BLISSc-ILD
Start date: September 13, 2023
Phase: Phase 3
Study type: Interventional

This study investigates the efficacy and safety of belimumab compared to placebo, in addition to standard therapy, for the treatment of participants with systemic sclerosis associated interstitial lung disease (SSc-ILD). The study will evaluate the effect of belimumab treatment on lung function as well as on extra-pulmonary disease manifestations, including skin thickening and general symptoms, such as fatigue, that impact quality of life (QoL).

NCT ID: NCT05878678 Recruiting - Breast Cancer Clinical Trials

Prospective Study of Particle Radiotherapy for Breast Cancer With Different Arm Position

Start date: May 15, 2023
Phase: Phase 2
Study type: Interventional

The optical body surface image (C-RAD) was used to guide and track the change of positions, and multimodal images (including 2D X-ray images, CT images and PET-CT images) were used to verify the treatment positions. In order to explore the accuracy of breast cancer patients' treatment positions and its impact on dose of the new fixation device in two different fixed positions of arm up and arm down, optimize the position fixed equipment and methods of particle radiotherapy for breast cancer, and then establish the precision process of particle radiotherapy for breast cancer under the guidance of multimodal images. In a word, this is a dosimetry and prospective Phase II randomized clinical study of the accuracy of multi-modal guided particle radiotherapy for postoperative breast cancer with different arm position.