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NCT ID: NCT04398420 Terminated - Clinical trials for Benign Prostatic Hypertrophy

Transurethral Vapor Enucleation Resection of the Prostate (TVERP), Bipolar TURis and HoLEP

Start date: August 27, 2020
Phase: N/A
Study type: Interventional

To verify the safety and efficacy of the use of the plasma vaporisation button in Transurethral Vapor Enucleation and Resection of the prostate (TVERP) for treatment of Benign prostatic hypertrophy (BPH) patients with prostate ˃30 and ≤80 ml compare to TURis or HoLEP surgery methods.

NCT ID: NCT04398134 Terminated - Chronic Hepatitis B Clinical Trials

A Study of ABI-H2158-containing Regimens in Participants With Chronic Hepatitis B Virus Infection

Start date: August 28, 2020
Phase: Phase 2
Study type: Interventional

This Phase 2a study will assess the safety, antiviral activity, and pharmacokinetics (PK) of ABI-H2158 administered once daily for up to 72 weeks in combination with entecavir (ETV) in participants with chronic hepatitis B virus (HBV) infection.

NCT ID: NCT04396366 Terminated - Bronchiectasis Clinical Trials

Study of Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of QBW251 in Subjects With Bronchiectasis

Start date: February 2, 2021
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine whether potentiating the cystic fibrosis transmembrane conductance regulator (CFTR) with QBW251 in patients with bronchiectasis will demonstrate clinical safety and efficacy related to improved mucociliary clearance with reduced bacterial colonization as potential drivers of airway obstruction, reduced airway inflammation, exacerbations and mucus load, improved lung function, clinical symptoms and quality of life to support further development in bronchiectasis.

NCT ID: NCT04383691 Terminated - Clinical trials for Bipolar I Depression

A Study of Lurasidone Compared With Placebo for the Treatment of Bipolar I Depression

Start date: December 11, 2020
Phase: Phase 3
Study type: Interventional

The study evaluates the efficacy and safety of lurasidone compared with placebo in treating Bipolar I Depression.

NCT ID: NCT04381325 Terminated - Clinical trials for Advanced Solid Tumor

A Study of MSB0254 Injection in Advanced Solid Tumors

Start date: April 1, 2020
Phase: Phase 1
Study type: Interventional

This study was an open, multi-dose dose escalation phase I clinical study to evaluate the safety, tolerability and PK characteristics of MSB0254 in patients with locally advanced or metastatic solid tumors, and to preliminarily measure its anti-tumor efficacy.

NCT ID: NCT04375085 Terminated - Clinical trials for Coronary Artery Disease

DESyne X2 Post Market Follow-up Study

Start date: September 1, 2020
Phase: N/A
Study type: Interventional

A single-arm post-market clinical follow-up study to confirm that the DESyne X2 delivery system performs similarly to the DESyne delivery system.

NCT ID: NCT04374253 Terminated - Alzheimer Disease Clinical Trials

A Study to Evaluate the Safety, Tolerability, and Efficacy of Long-Term Gantenerumab Administration in Participants With Alzheimer's Disease (AD)

Start date: January 26, 2021
Phase: Phase 3
Study type: Interventional

This is an open-label, multicenter, rollover study to evaluate the safety, tolerability, and efficacy of long-term administration of open-label gantenerumab in participants with AD who completed Study WN29922 or WN39658, either the double-blind or open-label extension (OLE) part.

NCT ID: NCT04371666 Terminated - Clinical trials for Duchenne Muscular Dystrophy

Phase 3 Trial of Pamrevlumab or Placebo With Systemic Corticosteroids in Participants With Non-ambulatory Duchenne Muscular Dystrophy (DMD)

LELANTOS-1
Start date: August 10, 2020
Phase: Phase 3
Study type: Interventional

To evaluate the efficacy and safety of pamrevlumab versus placebo in combination with systemic corticosteroids in participants with non-ambulatory Duchenne muscular dystrophy (age 12 years and older).

NCT ID: NCT04367116 Terminated - Clinical trials for Progressive Supranuclear Palsy

The Study to Evaluate the Safety and Efficacy of Spinal Cord Stimulation on Progressive Supranuclear Palsy

Start date: July 1, 2021
Phase: N/A
Study type: Interventional

The study is an open-label, prospective, single-arm, unicentral (Huashan Hospital Department of Neurology/ Neurosurgery) and exploratory clinical trial. Subjects will be enrolled from Parkinson's disease and Movement Disorder specialized outpatient department of Neurology in Huashan Hospital and network platform of chronic diseases. Spinal Cord Stimultion (SCS) will be performed in department of Neurosurgery and cerebral metabolism will be assessed in PET center of Huashan Hospital. Specialists in Neurology will follow up 3 months to record any unsafe incidents of progressive supranuclear palsy patients after the SCS surgery to evaluate safety. Meanwhile, improvement in gait disorder (including 10MWT and TUG test score) will be measured to evaluate efficacy.

NCT ID: NCT04352413 Terminated - Clinical trials for Small Cell Lung Cancer

A Study of PLM60 in Subjects With Relapsed Small-cell Lung Cancer After Platinum-based First-Line Chemotherapy

Start date: June 18, 2020
Phase: Phase 2
Study type: Interventional

This is an open, multicenter phase II clinical study for PLM60. The primary aim of the study is to observe the initial efficacy of PLM60 in treatment of small cell lung cancer. The secondary aim is to explore the safety and PK characteristics of PLM60