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NCT ID: NCT06346041 Recruiting - Neoplasms Clinical Trials

Safety and Efficacy of Intravenous IDOV-SAFETM in Patients With Advanced Solid Tumors

Start date: April 12, 2024
Phase: Early Phase 1
Study type: Interventional

This is an open-label, dose escalation, phase I study to evaluate safety tolerability, MTD or MFD, pharmacokinetic profile, immunogenicity, and pharmacodynamic profile of IDOV-SAFETM in patients with advanced solid tumors.

NCT ID: NCT06345898 Recruiting - Clinical trials for X Linked Retinoschisis

Safety and Efficacy of a Single Subretinal Injection of JWK002 Gene Therapy in Subjects With X-linked Retinoschisis(XLRS)

Start date: November 17, 2023
Phase: Early Phase 1
Study type: Interventional

This trial is to evaluate the safety and efficacy of JWK002 treatment of X-linked retinoschisis(XLRS). This study will enroll subjects aged 5-18 years old to receive a sub-retinal injection of JWK002.

NCT ID: NCT06345885 Completed - Clinical trials for Human Papillomavirus Vaccines

Immunogenicity and Safety of One Dose of HPV Vaccine

Start date: February 23, 2023
Phase: Phase 4
Study type: Interventional

This study will assess the immunogenicity and safety of one dose of Cecolin and one dose of Gardasil

NCT ID: NCT06345521 Recruiting - Heart Failure Clinical Trials

Etablishment of Follow-up System and End-Stage Heart Registration Platform for Pediatric Heart Failure

Start date: January 1, 2022
Phase:
Study type: Observational

Establish a follow-up management system for pediatric heart failure and a registration platform for end-stage heart failure

NCT ID: NCT06345482 Not yet recruiting - Clinical trials for Advanced Solid Tumor

A Study of MHB039A for Advanced Solid Tumor

Start date: April 1, 2024
Phase: Phase 1/Phase 2
Study type: Interventional

Phase I/II open label, multicenter study to evaluate the efficacy and safety of MHB039A in advanced malignant tumors.

NCT ID: NCT06345365 Recruiting - Clinical trials for Acute Myeloid Leukaemia

MA+AZA Regimen for the Treatment of Newly Diagnosed Acute Myeloid Leukemia (AML)

Start date: January 18, 2024
Phase: Phase 3
Study type: Interventional

Investigator proposed to apply the new dosage form of mitoxantrone hydrochloride liposomes to the clinical treatment of AML, while combining with cytarabine and azacitidine to form the MA+AZA treatment regimen(Mitoxantrone liposome +Ara-Cytarabine+Azacitidine), which would provide an optimal induction treatment regimen for patients with primary AML by comparing with the traditional chemotherapy regimen, DA+AZA (Daunorubicin+Ara-Cytarabine+Azacitidine).

NCT ID: NCT06345300 Recruiting - Clinical trials for Borderline Resectable Pancreatic Cancer

NALIRIFOX in Combination With Camrelizumab for BRPC: a Prospective, Exploratory Study

Start date: March 10, 2024
Phase: Phase 2
Study type: Interventional

The aim of this study is to assess the efficacy and safety of Liposomal Irinotecan, Oxaliplatin, 5-Fluorouracil/Calcium folinate in combination with Camrelizumab for patients with borderline resectable pancreatic cancer

NCT ID: NCT06345287 Recruiting - Clinical trials for Head and Neck Cancer

Response Adaptive Radiotherapy Following Immunotherapy-based Induction for Non-HPV Related HNSCC

Start date: January 1, 2024
Phase: Phase 2
Study type: Interventional

The aim of this study is to develop an adaptive radiation therapy plan for locally advanced head and neck squamous cell carcinoma receiving induction therapy containing immunotherapy and chemotherapy. The therapy plan is based on clinical remission, in order to reduce treatment-related toxic side effects without sacrificing clinical efficacy and improve the quality of life of patients.

NCT ID: NCT06345131 Recruiting - Surgical Patients Clinical Trials

Clinical Research Plan for the Safety and Accuracy of Ultrasound-guided Radial Artery Puncture Catheterization

Start date: July 1, 2023
Phase: N/A
Study type: Interventional

By observing the anatomical relationship and influencing factors of the radial artery through ultrasound, the optimal puncture location is selected, and puncture catheterization is guided to reduce the number of punctures, reduce complications, and improve safety and accuracy.

NCT ID: NCT06344962 Recruiting - Clinical trials for Suture, Complication

Clinical Effects of Absorbable and Non-absorbable Suture in Bronchial Sleeve Resection

Start date: February 28, 2023
Phase: N/A
Study type: Interventional

Bronchial sleeve resection is performed as an alternative to pneumonectomy for lung cancer patients with centrally located lesions and limited cardiopulmonary reserve. Intraoperative bronchial anastomosis is very complex and difficult, mainly due to the difficulty of suturing and knotting in limited space. There are currently few studies comparing the clinical effects of absorbable and non-absorbable suture in bronchial sleeve resection. So the investigator wants to conduct a prospective study, trying to figure out this problem.