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NCT ID: NCT05745610 Not yet recruiting - Clinical trials for Efficacy and Safety of Shen Hai Long Capsule for Mild to Moderate Asthenospermia in Men

Shen Hai Long Capsule for Male Asthenospermia

Start date: February 15, 2023
Phase: N/A
Study type: Interventional

To evaluate the efficacy and safety of Shen Hai Long Capsule in the treatment of mild to moderate asthenospermia in men.

NCT ID: NCT05744089 Not yet recruiting - Carcinoma Clinical Trials

Home Management of Simple Hydromorphone PCA Pump Mode

Start date: February 2023
Phase: N/A
Study type: Interventional

This prospective observational study will evaluate the efficacy and adverse effects of a "simple hydromorphone PCA pump model", which is a rapid titration followed by a convenient maintenance technique, to treat home cancer patients with severe or critical cancer pain or refractory cancer pain.

NCT ID: NCT05743972 Not yet recruiting - Pancreatic Disease Clinical Trials

Contrast-Enhanced Ultrasound vs Conventional US-guided Percutaneous Needle Biopsy for Pancreatic Diseases: Prospective Multicenter Randomized Controlled Trial

Start date: March 1, 2023
Phase: N/A
Study type: Interventional

According to previous studies, contrast-enhanced ultrasound (CEUS) -guided Core Biopsy(GB) could improve the diagnosis of biopsy in liver and other superficial mass compared to conventional US-GB. The purpose of this randomized trial is to estimate whether CEUS-GB achieve excellent diagnostic value to conventional US-GB in percutaneous biopsy for pancreatic diseases.

NCT ID: NCT05743751 Not yet recruiting - Clinical trials for Kidney Transplantation

Normothermic Machine Perfusion (NMP) Versus Hypothermic Machine Perfusion (HMP) in Human Kidney Transplantation

Start date: March 3, 2023
Phase: N/A
Study type: Interventional

Due to the rising incidence of renal failure and the improvement of organ transplantation technology, the shortage of donor organs has become one of the main problems limiting the development of kidney transplantation. Marginal donor is one of the important ways to extend the donor pool. Normothermic mechanical perfusion (NMP) is a new generation of organ preservation technology, which can maintain the blood supply and at the same time evaluate the marginal kidney function during the organ preservation. However, the clinical effect has not been proved. Hypothermic Machine Perfusion (HMP) is the mainstream organ perfusion technology. This study aims to compare the effectiveness of NMP with the HMP.

NCT ID: NCT05742750 Not yet recruiting - Clinical trials for Metastatic Biliary Tract Cancer

A Phase Ib/II Clinical Study of Camrelizumab and Apatinib Plus GP in the Treatment of Advanced Biliary Tract Cancer

Start date: March 1, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

The objective of this study is to investigate the safety and tolerability of camrelizumab combined with apatinib and chemotherapies (gemcitabine and cisplatin) in patients with advanced biliary tract cancer (BTC).

NCT ID: NCT05741021 Not yet recruiting - Clinical trials for Non-small Cell Lung Cancer

A Phase II Study of Rulonilimab Combined With Chemotherapy in the First-Line Treatment for Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

Start date: March 1, 2023
Phase: Phase 2
Study type: Interventional

This is a single-arm, open-label, and multicenter phase Ⅱ study designed to evaluate the efficacy and safety of rulonilimab combined with chemotherapy in patients with advanced or metastatic non-small cell lung Cancer (NSCLC). Two cohorts were designed in this study: cohort 1 (non-squamous NSCLC) and cohort 2 (squamous NSCLC). About 84 patients with advanced or metastatic NSCLC plan to be enrolled in about 20 study sites of the study.

NCT ID: NCT05740917 Not yet recruiting - AML Clinical Trials

To Evaluate the Phase I Clinical Study of XZB-0004 in Patients With AML and MDS

Start date: February 2023
Phase: Phase 1
Study type: Interventional

This is an open-label, multicenter Phase I study that will enroll patients with relapsed/refractory AML or MDS. Stage Ia and stage Ib are included in this study. Phase Ia is a single-agent dose-escalation study that enrolling R/R AML subjects to identify XZB-0004 monotherapy MTD (if any) and RP2D and evaluate its safety and pharmacokinetic profile. Phase Ib will be an expanded study in R/R AML patients (group 1) and R/R MDS patients (group 2) at RP2D doses to further evaluate and determine the efficacy and safety of XZB-0004 in R/R AML or R/R MDS patients.

NCT ID: NCT05739409 Not yet recruiting - Clinical trials for Acute Myelogenous Leukemia

LILRB4 STAR-T Cell Therapy for Monocytic Leukemia

Start date: February 2023
Phase: N/A
Study type: Interventional

This is a single-center,single-arm,open-label phase I clinical study to determine the safety and efficacy of LILRB4 STAR-T cells in Monocytic Leukemia subjects.

NCT ID: NCT05738629 Not yet recruiting - Dry Eye Disease Clinical Trials

Safety and Efficacy of Pluripotent Stem Cell-derived Mesenchymal Stem Cell Exosome (PSC-MSC-Exo) Eye Drops Treatment for Dry Eye Diseases Post Refractive Surgery and Associated With Blepharospasm

Start date: March 2023
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to evaluate the preliminary safety and effectiveness of Pluripotent Stem Cell-derived Mesenchymal Stem Cell Exosome (PSC-MSC-Exo) Eye Drops in the treatment of dry eye diseases post refractive surgery and associated with blepharospasm

NCT ID: NCT05738382 Not yet recruiting - Clinical trials for Assisted Reproductive Technology

Efficacy and Safety of BG2109 During Controlled Ovarian Hyperstimulation in Female Subjects Undergoing ART Procedures

Start date: August 2023
Phase: Phase 2
Study type: Interventional

To explore the optimal effective daily dose of BG2109 to suppress premature luteinizing hormone (LH) surge during COH in female subjects undergoing ART procedures.