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NCT ID: NCT06260839 Recruiting - Orthopedic Surgery Clinical Trials

the Effect of Minimally Invasive Technique Assisted by Magnetic Resonance Neurography

Start date: February 16, 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to to compare the therapeutic effect of minimally invasive surgery guided by magnetic resonance neurography(MRN) compared with non-magnetic resonance assisted minimally invasive surgery in patients with moderate to severe gluteal muscle contracture(GMC). The main question it aims to answer are: magnetic resonance neurography can better help optimize the surgical path of minimally invasive surgery in the treatment of gluteal muscle contracture. Participants will underwent preoperative magnetic resonance examination according to different groups, and then the experimental group designed individualized surgical approach and MRN-assisted minimally invasive release according to the imaging findings. In the control group, preoperative magnetic resonance examination was only used to assist in the diagnosis and evaluation of gluteal muscle contracture, and the magnetic resonance results were not used to assist in the design of surgical approach. In the control group, non-MRN-assisted minimally invasive release was performed. The researchers will compare the intraoperative surgery-related indicators and postoperative hip function scores and complications of patients in different groups to see if magnetic resonance-assisted surgery has a better postoperative effect.

NCT ID: NCT06260527 Recruiting - Clinical trials for Chinese Healthy Volunteer

Safety and Pharmacokinetic Study of ARTS-011 in Chinese Healthy Volunteers

Start date: August 30, 2023
Phase: Phase 1
Study type: Interventional

This single- and multiple-ascending dose study is a Phase 1, first in human study of ARTS-011. The goal of the study is to assess the safety, tolerability, pharmacokinetics, pharmacodynamics and food effect of ARTS-011 after single and multiple oral doses of ARTS-011 in Chinese healthy volunteers.

NCT ID: NCT06260163 Recruiting - Colitis, Ulcerative Clinical Trials

A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Ulcerative Colitis

QUASAR Jr
Start date: January 19, 2024
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy of guselkumab in pediatric participants with moderately to severely active ulcerative colitis at the end of maintenance therapy among participants who were induction responders.

NCT ID: NCT06259721 Recruiting - Clinical trials for Nasopharyngeal Carcinoma

Anti-PD1 Monoclonal Antibody Combined With Nimotuzumab and Capecitabine in Patients With First-line Platinum-resistant Recurrent/Metastatic Nasopharyngeal Carcinoma

Start date: February 10, 2024
Phase: Phase 2
Study type: Interventional

The purpose of this study is to explore the efficacy and safety of a combination regimen of Anti-PD1 monoclonal antibody, nimotuzumab, and capecitabin in treating recurrent or metastatic nasopharyngeal carcinoma patients who have failed first-line platinum-based chemotherapy.

NCT ID: NCT06259526 Recruiting - Depression Clinical Trials

A Study of the Effectiveness and Safety of JS1-1-01 in Patients With Moderate to Severe Depression

Start date: December 26, 2023
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the Effectiveness and Safety of JS1-1-01 in Patients With Moderate to Severe Depression

NCT ID: NCT06259149 Recruiting - Colorectal Cancer Clinical Trials

A Study of Initiation Timing of VTE Prevention After Colorectal Cancer Surgery

Start date: February 1, 2024
Phase:
Study type: Observational

This project intends to conduct a single-center, prospective, observational cohort study to explore the impact of the timing of drug prophylaxis on the risk of postoperative bleeding and the preventive effect of VTE in the prevention and management of postoperative venous thromboembolism (VTE) after colorectal cancer (CRC) surgery in Chinese population, and to determine its application and promotion value. The research results of this project can provide useful reference for optimizing the prevention and management of VTE after CRC operation.

NCT ID: NCT06258811 Recruiting - Clinical trials for Oral Squamous Cell Carcinoma

Neoadjuvant Immunochemotherapy for LAOSCC

Start date: February 20, 2024
Phase: Phase 3
Study type: Interventional

To evaluate the prognostic efficacy of neoadjuvant immunochemotherapy with tislelizumab, albumin paclitaxel and cisplatin followed by radical surgery and adjuvant therapy compared with standard therapy for patients with locally advanced and resectable oral squamous cell carcinoma.

NCT ID: NCT06258460 Recruiting - Mental Illness Clinical Trials

Multimodal Psychotherapy Training for Chinese Medical Students

Start date: February 1, 2014
Phase: N/A
Study type: Interventional

Providing evidence-based, well-designed psychotherapy teaching to train them to get a basic understanding of psychotherapy and to gain required skills for clinical practice would be fundamental to medical students, residency. This study will be a two-arm randomized controlled trial (RCT) to evaluate the effectiveness of multimodal psychotherapy training program for medical students in China.

NCT ID: NCT06258408 Recruiting - Clinical trials for Advanced Solid Tumor

A Phase 1 Study of BB102 in Participants With Advanced Solid Tumors

Start date: December 29, 2022
Phase: Phase 1
Study type: Interventional

This is a Phase 1 study to evaluate the safety, tolerability, pharmacokinetics, efficacy and preliminary food effect of BB102, a highly selective and potent FGFR4 inhibitor, as monotherapy in subjects with advanced solid tumors. This study has two phase: dose escalation phase and expansion phase.

NCT ID: NCT06257043 Recruiting - Clinical trials for Aortic Valve Disease Mixed

Safety and Efficacy of Post-marketing Transcatheter Aortic Valves in "Real World" Chinese Patients

Start date: October 30, 2023
Phase:
Study type: Observational [Patient Registry]

The purpose of this prospective multi-center, observational registry in China is to collect clinical baseline, procedural, and follow-up data of all patients treated with TAVR in China and to evaluate short-, mid-, and long-term clinical outcome data of all post-marketing transcatheter valves. Each center will collect baseline and procedural data as well as clinical outcomes for up to 10 years.