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NCT ID: NCT00123591 Completed - Trauma Clinical Trials

Safety and Preliminary Efficacy of Recombinant Activated Factor VII in Subjects With Traumatic Brain Injury

Start date: January 2005
Phase: Phase 2
Study type: Interventional

This trial is conducted in Asia, Europe, Middle East, and North America. The primary objective of the trial is to evaluate the safety of Recombinant Activated Factor VII in patients with brain contusions. The secondary objective of the trial is to evaluate the preliminary efficacy of Recombinant Activated Factor VII in preventing early haemorrhagic progression in contusive brain injury.

NCT ID: NCT00123487 Completed - Clinical trials for Leukemia, Lymphoblastic, Acute, Philadelphia-Positive

Advanced Chronic Myelogenous Leukemia (CML) - Follow On: Study of BMS-354825 in Subjects With CML

Start date: June 2005
Phase: Phase 3
Study type: Interventional

This is a phase III study of BMS-354825 in subjects with chronic myelogenous leukemia in accelerated phase, or in myeloid or lymphoid blast phase or with Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia who are resistant or intolerant to imatinib mesylate (Gleevec).

NCT ID: NCT00123474 Completed - Clinical trials for Myeloid Leukemia, Chronic, Chronic-Phase

Chronic Myelogenous Leukemia (CML) - Follow on: Study of BMS-354825 in Subjects With CML

Start date: July 2005
Phase: Phase 3
Study type: Interventional

This is a phase III study of BMS-354825 in subjects with chronic phase Philadelphia chromosome or BCR-ABL positive chronic myelogenous leukemia, who are resistant or intolerant to imatinib mesylate (Gleevec).

NCT ID: NCT00122798 Completed - Stroke Clinical Trials

Improved Stroke Outcome at 6 Months

Start date: January 2002
Phase: Phase 4
Study type: Observational

The investigators implemented a structured chain of acute stroke care with early integrated rehabilitation. The mortality at 6 months was lower (12%) compared to 23% in the International Stroke Trial (IST) and 39% (67%) of the patients were dead or dependent, which is superior compared to international data.

NCT ID: NCT00122460 Completed - Clinical trials for Head and Neck Cancer

Cetuximab (Erbitux) in Combination With Cisplatin or Carboplatin and 5-Fluorouracil in the First Line Treatment of Subjects With Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck (EXTREME)

Start date: December 2004
Phase: Phase 3
Study type: Interventional

The purpose of this trial is to investigate the efficacy of cetuximab in combination with chemotherapy in comparison to chemotherapy alone in patients with recurrent or metastatic head and neck cancer. Overall survival will be taken as the primary measure of efficacy.

NCT ID: NCT00122330 Completed - Clinical trials for Hemoglobinuria, Paroxysmal

Study Using Eculizumab in Transfusion Dependent Paroxysmal Nocturnal Hemoglobinuria (PNH) Patients

Start date: October 2004
Phase: Phase 3
Study type: Interventional

The primary objective is to evaluate the safety and efficacy of eculizumab in transfusion dependent patients with hemolytic PNH.

NCT ID: NCT00122304 Completed - Clinical trials for Hemoglobinuria, Paroxysmal

Study of Safety in Hemolytic Paroxysmal Nocturnal Hemoglobinuria (PNH) Patients Treated With Eculizumab

Start date: December 2004
Phase: Phase 3
Study type: Interventional

The primary objective is to evaluate the safety of eculizumab in patients with transfusion-dependent hemolytic PNH

NCT ID: NCT00121316 Completed - Atopic Dermatitis Clinical Trials

Safety and Efficacy of Pimecrolimus Cream 1% in Mild to Moderate Head and Neck Atopic Dermatitis (AD) Patients

Start date: October 2004
Phase: Phase 4
Study type: Interventional

This study is not being conducted in the United States. Patients who are intolerant of topical corticosteroids (TCS) have either experienced an adverse event resulting from the use of TCS, or require unacceptable levels of exposure to TCS in order to control their AD. This is of particular concern for patients with recurrent flares on delicate skin areas such as the head and neck. The purpose of this study is to investigate whether pimecrolimus cream 1%, a non-steroidal anti-inflammatory drug, is efficacious in treating mild to moderate head and neck AD in patients who are intolerant of, or dependent on topical corticosteroids.

NCT ID: NCT00119717 Completed - Clinical trials for Cerebrovascular Accident

Safety and Efficacy of NeuroFlo Technology in Ischemic Stroke (SENTIS)

SENTIS
Start date: June 2005
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess the safety and efficacy of the NeuroFlo™ catheter for use in patients with ischemic stroke. The NeuroFlo device is intended to increase blood flow to the brain and potentially reduce the damage caused by stroke.

NCT ID: NCT00117598 Completed - Lymphoma Clinical Trials

Study Evaluating Temsirolimus (CCI-779) In Mantle Cell Lymphoma (MCL)

OPTIMAL
Start date: May 2005
Phase: Phase 3
Study type: Interventional

This is an open-label, randomized trial in relapsed refractory subjects with mantle cell lymphoma (MCL).