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NCT ID: NCT03274492 Active, not recruiting - Clinical trials for Diffuse Large B-Cell Lymphoma

A Study Comparing the Efficacy and Safety of Polatuzumab Vedotin With Rituximab-Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab-Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Diffuse Large B-Cell Lymphoma

POLARIX
Start date: November 16, 2017
Phase: Phase 3
Study type: Interventional

This Phase III, randomized, double-blind, placebo-controlled study will compare the efficacy, safety, and pharmacokinetics of polatuzumab vedotin plus R-CHP versus R-CHOP in participants with previously untreated diffuse large B-cell lymphoma (DLBCL).

NCT ID: NCT03266874 Active, not recruiting - Clinical trials for Rheumatoid Arthritis

G7 BiSpherical Acetabular Shell PMCF Study

Start date: December 10, 2017
Phase:
Study type: Observational

The primary objective of this study is to obtain implant survivorship and clinical outcomes data for the commercially available G7 BiSpherical Acetabular Shell.

NCT ID: NCT03256981 Active, not recruiting - NSCLC Clinical Trials

Stereotactic Body Radiotherapy for the Treatment of OPD

HALT
Start date: November 27, 2017
Phase: Phase 2/Phase 3
Study type: Interventional

HALT is a phase II, randomised multi-centre study with integrated seamless continuation to phase III trial following acceptable safety and feasibility assessment. HALT aims to recruit 110 patients with mutation positive advanced NSCLC with oligoprogressive disease (OPD) following initial response to a Tyrosine Kinase Inhibitor (TKI).

NCT ID: NCT03227757 Active, not recruiting - Clinical trials for Tricuspid Valve Insufficiency

TRILUMINATE Study With Abbott Transcatheter Clip Repair System in Patients With Moderate or Greater TR

TRILUMINATE
Start date: August 1, 2017
Phase: N/A
Study type: Interventional

The primary purpose of this study is to evaluate safety and effectiveness of the Tricuspid Valve Repair System (TVRS) for treating symptomatic moderate or greater tricuspid regurgitation (TR) in patients currently on medical management and who are deemed appropriate for percutaneous transcatheter intervention.

NCT ID: NCT03227146 Active, not recruiting - Burns Clinical Trials

Study With an Autologous Dermo-epidermal Skin Substitute for the Treatment of Burns in Adults and Adolescents

Start date: October 25, 2017
Phase: Phase 2/Phase 3
Study type: Interventional

This phase IIb trial aims to evaluate the efficacy and safety of EHSG-KF (synonym denovoSkin) in comparison to meshed STSG in adults and adolescents with partial deep dermal and full thickness burns.

NCT ID: NCT03217422 Active, not recruiting - Clinical trials for Autoimmune Hepatitis

ADCC Mediated B-Cell dEpletion and BAFF-R Blockade

AMBER
Start date: February 15, 2018
Phase: Phase 2/Phase 3
Study type: Interventional

VAY736 dose testing; VAY736 efficacy and safety testing.

NCT ID: NCT03216187 Active, not recruiting - Clinical trials for Persistent Postoperative Pain

Swiss Multi-centre, Randomized, Placebo Controlled Trial of Pregabalin for Prevention of Persistent Pain in High Risk Patients Undergoing Breast Cancer Surgery

PREVENT
Start date: January 9, 2018
Phase: Phase 3
Study type: Interventional

This study will test the benefits and risks of using pregabalin perioperatively to prevent persistent postoperative pain in patients at high risk (>30%) of developing such pain after breast cancer surgery.

NCT ID: NCT03211546 Active, not recruiting - Clinical trials for Femoral Shaft Fracture

Pediatric Femur Fracture Registry

PedFemFx
Start date: March 14, 2018
Phase:
Study type: Observational [Patient Registry]

Prospective data collection and evaluation of complete data sets will be performed in the course of routine clinical care of a cohort of consecutive patients (children up to 16 years old) presenting with an isolated femur shaft fracture. Data will be collected during follow-up visits at 3 to 6 weeks, 3, 6, 12 and 24 months, with additional follow-up visits as needed or dictated by individual practice. Final follow-up will be at 24 months, unless a patient requires additional follow-up or another intervention to address an unfavorable outcome (e.g. malalignment, nonunion, limb length discrepancy) noted at the 24 month follow-up visit.

NCT ID: NCT03193476 Active, not recruiting - Clinical trials for X-Linked Hypophosphatemia

Registry for Patients With X-Linked Hypophosphatemia

Start date: September 12, 2017
Phase:
Study type: Observational [Patient Registry]

This is an international, multicentre, prospective, non-interventional, observational Registry of patients with X-Linked hypophosphatemia (XLH). The main objective of this XLH Registry is to collect data to characterise the treatment, progression and long-term outcomes of XLH in both adult and paediatric settings.

NCT ID: NCT03183895 Active, not recruiting - Heart Failure Clinical Trials

Evaluate the Safety and Performance of the AccuCinch® Ventricular Repair System - The CorCinch-EU Study

Start date: January 15, 2019
Phase: N/A
Study type: Interventional

This is prospective, non-randomized, single-arm, international, multicenter, clinical safety and performance clinical investigation to evaluate the AccuCinch® Ventricular Repair System for the treatment of heart failure, with or without functional mitral regurgitation due to dilated ischemic or non-ischemic cardiomyopathy