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NCT ID: NCT00676143 Terminated - Alzheimer Disease Clinical Trials

Study Evaluating the Safety and Efficacy of Bapineuzumab in Alzheimer Disease Patients

Start date: May 2008
Phase: Phase 3
Study type: Interventional

This is a study to evaluate the efficacy and safety of multiple doses of bapineuzumab in patients with mild to moderate Alzheimer Disease. Patients will receive either bapineuzumab or placebo. Each patient's participation will last approximately 1.5 years.

NCT ID: NCT00675116 Completed - Healthy Subjects Clinical Trials

GW823296 Repeat Dose Study In Healthy Male And Female Subjects

Start date: April 2008
Phase: Phase 1
Study type: Interventional

This is a study to evaluate the safety, tolerability and pharmacokinetics of GW823296 following 28 days, once-daily repeat oral doses.

NCT ID: NCT00675090 Completed - Alzheimer's Disease Clinical Trials

Bridging Study With GSK239512 In Patients With Mild To Moderate Alzheimer's Disease

Start date: February 21, 2008
Phase: Phase 1
Study type: Interventional

This is a safety and tolerability study to investigate the effect of GSK239512 on mild to moderate Alzheimers disease patients. The dose of GSK239512 will be titrated to reach the most well tolerated dose in the patients.

NCT ID: NCT00674973 Completed - Pancreatic Cancer Clinical Trials

A Biomarker Identification Trial of Tarceva (Erlotinib) in Patients With Advanced Pancreatic Cancer

Start date: June 2008
Phase: Phase 2
Study type: Interventional

This study is designed to identify biomarkers which may predict improvement in progression free survival from treatment with Tarceva, in patients with advanced pancreatic cancer who failed one prior regimen of standard chemotherapy or who are deemed unsuitable for chemotherapy. It will also assess the efficacy and safety of Tarceva in this patient population. Patients will be randomized to receive either Tarceva 150mg/day po, or placebo po daily. Tumor tissue will be used for biomarker analysis. The anticipated time on study treatment is until disease progression, and the target sample size is 100-500 individuals.

NCT ID: NCT00674635 Completed - Clinical trials for Arthritis, Rheumatoid

Phase II Study Evaluating the Safety and Efficacy of GSK315234A in Patients With Rheumatoid Arthritis

Start date: April 2008
Phase: Phase 2
Study type: Interventional

This is a randomized, double-blinded, placebo-controlled adaptive, dose finding study to investigate the safety, tolerability, PK, PD and efficacy of single and repeat intravenous infusions of GSK315243A in patients with active rheumatoid arthritis. The study is divided into 2 parts: Part A is an adaptive, dose finding phase which will provide safety, tolerability, PK and PD on single intravenous infusions. Part B is a repeat dose phase which will provide safety, tolerability, PK, PD and efficacy following repeat intravenous infusions of a selected dose level.

NCT ID: NCT00674193 Completed - Clinical trials for Unspecified Childhood Solid Tumor, Protocol Specific

Evaluating Dactinomycin and Vincristine in Young Patients With Cancer

Start date: February 2008
Phase: N/A
Study type: Observational

This laboratory study is evaluating how well dactinomycin and vincristine work in treating young patients with cancer. Studying samples of blood and urine in the laboratory from patients with cancer may help doctors learn how dactinomycin and vincristine affect the body and how patients will respond to treatment.

NCT ID: NCT00673894 Completed - Type 2 Diabetes Clinical Trials

Effects of Glutamine on GLP-1 and Insulin Secretion in Man

Start date: April 2008
Phase: N/A
Study type: Interventional

This study investigated the effect of glutamine, an amino acid, glycemia, glucagon-like peptide-1 (GLP-1) and insulin in participants with type 2 diabetes.

NCT ID: NCT00673608 Completed - Clinical trials for Myelodysplastic Syndromes

Magnetic Resonance Imaging (MRI) Assessments of the Heart and Liver Iron Load in Patients With Transfusion Induced Iron Overload

Start date: November 2007
Phase: Phase 4
Study type: Interventional

This study will evaluate the change in cardiac iron load over a 53 week period measured by MRI in 2 cohorts of patients

NCT ID: NCT00673257 Completed - Clinical trials for Unspecified Childhood Solid Tumor, Protocol Specific

Pharmacokinetics of Daunorubicin in Young Patients With Cancer

Start date: January 2007
Phase: N/A
Study type: Interventional

This laboratory study is looking at the pharmacokinetics of daunorubicin in young patients with cancer. Collecting and storing samples of blood from patients with cancer to study in the laboratory may help doctors learn more about how patients respond to treatment with certain chemotherapy drugs.

NCT ID: NCT00673205 Completed - Clinical trials for Non-Metastatic Prostate Cancer

(Bicalutamide) Casodex vs Placebo in Non-metastatic Early Prostate Cancer

Capri
Start date: September 1995
Phase: Phase 3
Study type: Interventional

The purpose of this trial is to study the effect of adjuvant or immediate hormonal therapy, versus placebo, in subjects who have either undergone a primary therapy (principally radical prostatectomy or radiotherapy) or who were otherwise to be managed by watchful waiting.