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NCT ID: NCT04314986 Completed - Healthy Volunteers Clinical Trials

Multiple Ascending Dose Study of AR882 in Healthy Adult Male Volunteers

Start date: June 28, 2019
Phase: Phase 1
Study type: Interventional

A study to assess multiple ascending doses of AR882 in healthy adult males.

NCT ID: NCT04314362 Completed - Clinical trials for Meibomian Gland Dysfunction

Methods to Enhance AZR-MD-001 for Meibomian Gland Dysfunction (MGD)

Start date: July 14, 2020
Phase: Phase 2/Phase 3
Study type: Interventional

Single-center, single-masked (the individual(s) performing efficacy and safety measures will be masked to treatment assignment for the patient(s) they are assessing), vehicle-controlled, randomized study.

NCT ID: NCT04313608 Completed - B-cell Lymphoma Clinical Trials

A Study Evaluating the Safety and Efficacy of Glofitamab or Mosunetuzumab in Combination With Gemcitabine Plus Oxaliplatin in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma and High-Grade Large B-Cell Lymphoma

Start date: June 4, 2020
Phase: Phase 1
Study type: Interventional

This study is designed to evaluate the safety and efficacy of glofitamab or mosunetuzumab in combination with gemcitabine and oxaliplatin (Glofit-GemOx or Mosun-GemOx) in participants with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) or high-grade B-cell lymphoma (HGBCL).

NCT ID: NCT04313166 Completed - Clinical trials for Amyotrophic Lateral Sclerosis

Treatment Continuation Study for Patients With ALS/MND Who Completed Study CMD-2019-001

Start date: March 19, 2020
Phase: Phase 2
Study type: Interventional

Provides up to six months treatment with CuATSM for subjects who have successfully completed study CMD-2019-001

NCT ID: NCT04308681 Completed - Pulmonary Fibrosis Clinical Trials

A Study Measuring the Effectiveness, Safety, and Tolerability of BMS-986278 in Participants With Lung Fibrosis

Start date: July 29, 2020
Phase: Phase 2
Study type: Interventional

The purpose of this study is to provide an initial evaluation of the effectiveness of BMS-986278 in participants with lung fibrosis, to demonstrate the safety of BMS-986278, and provide information on the drug levels of BMS-986278 in these participants.

NCT ID: NCT04307173 Completed - Clinical trials for Moderate to Severe Asthma

Study of Multiple Ascending Dose of KBL693 in Healthy Participants

Start date: August 14, 2020
Phase: Phase 1
Study type: Interventional

The study is designed to investigate the safety and tolerability of KBL693 in healthy volunteers. KBL693 has been developed as a potential new treatment for moderate to severe asthma..

NCT ID: NCT04304508 Completed - Clinical trials for Acute Non-cardioembolic Ischemic Stroke

Study to Gather Information About Proper Dosing and Safety of the Oral FXIa Inhibitor BAY 2433334 in Patients Following a Recent Non Cardioembolic Ischemic Stroke Which Occurs When a Blood Clot Has Formed Somewhere in the Human Body (But Not in the Heart) Travelled to the Brain.

PACIFIC-STROKE
Start date: June 15, 2020
Phase: Phase 2
Study type: Interventional

The purpose of this study is to try to find the best dose of the new drug BAY 2433334 to give to participants and to look at how well BAY 2433334 works on top of antiplatelet therapy in patients following a recent non cardioembolic ischemic stroke which occurs when a blood clot that has not formed in the heart travelled to the brain. BAY 2433334, works by blocking a step of the blood clotting process in our body and thins the blood and is a so called oral FXIa inhibitor.

NCT ID: NCT04304482 Completed - Rett Syndrome Clinical Trials

ANAVEX2-73 Study in Pediatric Patients With Rett Syndrome

EXCELLENCE
Start date: July 1, 2020
Phase: Phase 2/Phase 3
Study type: Interventional

ANAVEX2-73-RS-003 is a Phase 2/3, double-blind, randomized, placebo-controlled dose escalation safety, tolerability and efficacy study in patients 5-17 years of age with RTT using endpoints including multiple clinical and exploratory molecular and biochemical measures.

NCT ID: NCT04303455 Completed - Shock Clinical Trials

Renin as a Biomarker of Haemodynamic Normalisation

Start date: March 24, 2020
Phase:
Study type: Observational

Study design Observational, single centre, prospective cohort study Planned sample size 100 participants Inclusion criteria The study will evaluate a cohort of participants meeting the following inclusion criteria: 1. admission to the Intensive Care Unit (ICU) after elective and emergency cardiac surgery using cardiopulmonary bypass 2. age 18 years and above 3. arterial, central venous and pulmonary arterial catheters have been inserted as part of routine care Study procedures In addition to routine clinical postoperative data and blood collection, serum renin levels will be analysed on admission, 6 and 24 hours after admission to ICU Study duration 6 months

NCT ID: NCT04301804 Completed - Healthy Volunteers Clinical Trials

A Trial of SHR6390 in Healthy Caucasian Volunteers

Start date: March 12, 2020
Phase: Phase 1
Study type: Interventional

This is a Phase 1, single center, single dose, open-label clinical study to evaluate the pharmacokinetics, safety and tolerability of SHR6390 under fasting conditions in healthy caucasian volunteers