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NCT ID: NCT04353102 Completed - Clinical trials for Advanced Solid Malignancies

A Study to Evaluate the Safety, Tolerability and How YH002 Enters, Moves Through and Exits the Body in Subjects With Advanced Solid Malignancies

Start date: April 22, 2020
Phase: Phase 1
Study type: Interventional

This is an open-label, dose-escalation study of the study drug YH002. The study is designed to determine the safety, tolerability and maximum tolerated dose (MTD) and recommended Phase 2 dose (RP2D) of YH002 in patients with advanced solid Malignancies

NCT ID: NCT04351165 Completed - Solid Tumor Clinical Trials

BA Study of IMP4297 (20mg vs 10mg) in Healthy Male Subjects

Start date: October 29, 2020
Phase: Phase 1
Study type: Interventional

An open-label, randomized, single-dose, 2-way crossover study to compare the bioavailability of two IMP4297 formulations (20 mg capsules and 10 mg capsules) after single oral administration of 100 mg IMP4297 under fasted condition in healthy male subjects

NCT ID: NCT04350008 Completed - Medical Devices Clinical Trials

BIO|CONCEPT.Renamic Neo Study

Start date: June 8, 2020
Phase:
Study type: Observational

The BIO|CONCEPT.Renamic.Neo study is designed as a pre-market study to provide clinical data and supporting evidence of the safety, performance and usability of the Renamic Neo programmer system.

NCT ID: NCT04349969 Completed - Neoplasms Malignant Clinical Trials

A Study to Evaluate the Safety, Pharmacokinetics, and Antitumor Activity of AK117 as Monotherapy or in Combination With AK104

Start date: April 23, 2020
Phase: Phase 1
Study type: Interventional

This was a first-in-human, Phase 1 study designed to evaluate the safety, tolerability, PK, immunogenicity, pharmacodynamics, and preliminary antitumor activity of AK117 as monotherapy or in combination with AK104 in subjects with advanced or metastatic solid tumors.

NCT ID: NCT04347005 Completed - Healthy Volunteers Clinical Trials

The Study is Designed to Evaluate Single Ascending Doses of AR882 in Healthy Adult Males

Start date: January 22, 2019
Phase: Phase 1
Study type: Interventional

A randomized, double-blind, placebo-controlled, single ascending dose study of AR882 in healthy adult males.

NCT ID: NCT04346316 Completed - Alopecia Areata Clinical Trials

A Phase II Study in Patients With Alopecia Areata

Start date: May 13, 2020
Phase: Phase 2
Study type: Interventional

This is a global Phase 2 study to evaluate the safety and effectiveness of an investigational study drug (called SHR0302) in adults with moderate to severe alopecia areata.

NCT ID: NCT04345367 Completed - Atopic Dermatitis Clinical Trials

Study of Abrocitinib Compared With Dupilumab in Adults With Moderate to Severe Atopic Dermatitis on Background Topical Therapy

Start date: June 11, 2020
Phase: Phase 3
Study type: Interventional

This is a randomized, double-blind, double-dummy, active-controlled, multi-center study to assess the efficacy and safety of abrocitinib 200 mg (2 x 100 mg tablets) administered orally QD compared with dupilumab 300 mg administered by subcutaneous injection every other week (as per label guidelines) in adult participants on background topical therapy, with moderate to severe AD. The treatment duration is 26 weeks. A total of approximately 600 participants will be enrolled from approximately 220 sites globally. Approximately 600 participants will be randomly assigned to study intervention. There are primary efficacy assessments at Week 2 and Week 4, and a key secondary efficacy assessment at Week 16. Efficacy and safety endpoints will be assessed throughout the entire study. Exploratory endpoints related to hand eczema efficacy will be assessed throughout the study.

NCT ID: NCT04344964 Completed - Colon Polyp Clinical Trials

Endoscopy-related Phone Consultation During the COVID-19 Outbreak

Start date: April 15, 2020
Phase:
Study type: Observational

The aim of this study is to evaluate patient and consultant experiences with phone consultations for endoscopy-related outpatient appointments during the COVID-19 outbreak.

NCT ID: NCT04344314 Completed - Clinical trials for Indication for Peripheral Intravenous Catheterisation

Impact of PIVC Length and Gauge on Catheter Indwell Time

Start date: August 31, 2020
Phase: N/A
Study type: Interventional

This is a single-centre, open-label, multi-visit study design, in 40 healthy participants, randomized by gauge of peripheral intravenous catheter (PIVC) device into the lower arm cephalic vein of both arms. The purpose of this study is to assess impact of catheter length and gauge on PIVC indwell time over a 72 hour period. This study will also evaluate the incidence of haemolysis using blood draws from the PIVC.

NCT ID: NCT04334980 Completed - COVID-19 Clinical Trials

Evaluating the Safety, Tolerability and Immunogenicity of bacTRL-Spike Vaccine for Prevention of COVID-19

Start date: November 2, 2020
Phase: Phase 1
Study type: Interventional

Protocol bacTRL-Spike-1 will be the first-in-human study of bacTRL-Spike, and the first-in-human use of orally delivered bacTRL. Each oral dose of bacTRL-Spike contains bacterial medium with either 1 billion (Group 1A), 3 billion (Group 2A) or 10 billion (Group 3A) colony-forming-units of live Bifidobacterium longum, which has been engineered to deliver plasmids containing synthetic DNA encoding spike protein from SARS-CoV-2.