Coronary Disease Clinical Trial
Official title:
ß2 Adrenergic Receptor Polymorphisms and Vasodilation of Internal Mammary Artery Induced by Isoproterenol
Single nucleotide polymorphisms at codon 46 and 79 of the gene encoding for the ß2
adrenergic receptor (ß2AR) modify its pharmacological properties and may alter the response
to ß2AR agonists. The goal of the present study was to evaluate the role played by the
Arg16Gly and Gln27Glu polymorphisms on isoproterenol induced relaxation of internal mammary
arteries segments ex-vivo.
Internal mammary leftover segments were collected from 96 patients undergoing coronary
artery bypass graft operation. Four rings that were prepared from each specimen were allowed
to reach equilibrium with physiological Krebs solution prior to precontraction with U46619.
Using the organ bath technique, cumulative dose response curve of isoproterenol was
constructed and mean EC50 calculated for each patient.
n/a
Allocation: Non-Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label
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