Predictors of Postoperative Atrial Fibrillation After CABG

Coronary Artery Disease Clinical Trial

— CODA-AF  

Official title:

A Comprehensive Observational Study on the Determinants of Postoperative Atrial Fibrillation in Patients Undergoing Coronary Artery Bypass Grafting

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT05888168
• Other study ID #: 2023065X
• Status: Active, not recruiting
• Start date: January 1, 2018
• Est. completion date: May 1, 2024

Study information

• Verified date: June 2023
• Source: Beijing Anzhen Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This observational study aims to identify the determinants or predictors of postoperative atrial fibrillation (POAF) in patients who have undergone coronary artery bypass grafting (CABG). The study will compare two cohorts: patients who developed POAF and those who did not (non-POAF), with the aim of improving postoperative care, reducing complications, and refining patient risk stratification.

Description:

Demographics (age, sex, ethnicity), lifestyle factors (smoking, alcohol, physical activity), and medical history (diabetes, hypertension, prior heart diseases) will be recorded. Surgical procedure details (number of grafts, use of intraoperative devices), anesthesia, and medications administered. Levels of inflammatory markers, cardiac-specific markers, and other relevant biomarkers at baseline and postoperatively. Other complications besides POAF, hospital length of stay, ICU admission, readmission rate, and mortality will also be monitored.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 15000
• Est. completion date: May 1, 2024
• Est. primary completion date: December 15, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Adults aged 18 years or older.

• Patients who underwent CABG.

Exclusion Criteria:

• Patients with a history of preoperative atrial fibrillation or other significant arrhythmias.

• Patients who underwent other concurrent cardiac procedures (e.g., valve surgery) in addition to CABG.

• Patients who cannot provide informed consent or lack adequate follow-up information.

Related Conditions & MeSH terms

• Atrial Fibrillation
• Atrial Fibrillation New Onset
• Coronary Artery Disease

Intervention

Procedure:
• CABG
All participants in the study will undergo the standard procedure of CABG. Continuous electrocardiogram monitoring and electrocardiography were used to identify the cardiac rhythm.

Locations

Country	Name	City	State
China	Beijing Anzhen Hospital	Beijing

Sponsors (1)

Lead Sponsor	Collaborator
Kun Hua

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Incidence of POAF	This will be determined based on electrocardiograms (ECG) and/or relevant medical records, within 30 days post-CABG.	During hospital stay, up to 30 days
Secondary	Hospital length of stay		During hospital stay, up to 30 days
Secondary	ICU admission time		During hospital stay, up to 30 days
Secondary	Number of participants with Stroke		During hospital stay, up to 30 days
Secondary	Mortality		During hospital stay, up to 30 days