Neointimal Features in Patients With Restenosis of Calcified Lesions

Status Recruiting

Clinical Trial Summary

Previous studies have suggested that restenosis (RS) after stenting is mainly due to smooth muscle cell proliferation and migration, but recent evidence suggests that in-stent restenosis（ISR） is associated with a number of factors. Coronary artery calcification is an independent predictor of ischaemia-mediated revascularisation 1 year after percutaneous coronary intervention (PCI) following RS.The characteristics of new neointima in patients with in-stent restenosis of calcified lesions are important issues to explore

Clinical Trial Description

The characteristics of the endothelium after DES following implantation of calcified lesions have always been of interest to us. Its inherent peculiarities make the new endothelium of calcified lesions different. Firstly, the presence of calcification makes the neointima heal slowly. In addition DES has an anti-proliferative effect, which further diminishes the healing ability of the neointima of calcified lesions and impairs the barrier function of the endothelium. This may have a similar pathway to the formation of neointimal atherosclerosis or heterogeneous endothelium within the neointima. Secondly, stents with calcified lesions can be accompanied by incomplete stent expansion, stent fracture and stent misalignment. These conditions may accelerate the occurrence of restenosis within the stent. Thirdly, there are different types of calcified lesions. Different types of calcified lesions may heal and restenosis in different ways. It is therefore understood that calcified lesion healing has a number of pathways that exist in contradiction. These are issues that need to be explored in depth. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05451368
Study type	Observational
Source	Shenyang Northern Hospital
Contact	geng wang, M.D.
Phone	13309886393
Email	wanggeng69@163.com
Status	Recruiting
Phase
Start date	March 17, 2022
Completion date	March 31, 2023

View Details

See also
Status	Clinical Trial	Phase
Unknown status	`NCT02498457` - The Effects and Safety of Low Calcium Dialysis on Coronary Artery Calcification in Maintenance Hemodialysis Patients	N/A
Completed	`NCT00379899` - ADVANCE: Study to Evaluate Cinacalcet Plus Low Dose Vitamin D on Vascular Calcification in Subjects With Chronic Kidney Disease Receiving Hemodialysis	Phase 4
Completed	`NCT03314493` - Prevention of the Progression of Coronary Calcification With Use of Spironolactone in Peritoneal Dialysis Patients	Phase 3
Recruiting	`NCT05346068` - The Value of IVL Compared To OPN Non-Compliant Balloons for Treatment of RefractorY Coronary Lesions (VICTORY) Trial	N/A
Completed	`NCT02966028` - Effect of SNF472 on Progression of Cardiovascular Calcification in End-Stage-Renal-Disease (ESRD) Patients on Hemodialysis (HD)	Phase 2
Completed	`NCT01992848` - MAP-Calcification: MicroRNAs as Potential Biomarkers for Coronary Artery Calcification	N/A
Recruiting	`NCT06181240` - Modification of Coronary Calcium With Laser Based Intravascular Lithotripsy for Coronary Artery Disease (FRACTURE)	N/A
Terminated	`NCT05508893` - Screening for Coronary Artery Disease USing Primary Evaluation With Coronary CTA in Aviation Medicine (SUSPECT)	N/A
Recruiting	`NCT06075602` - COMPLEX Registry - A Prospective COhort Study to Describe the Management and Outcomes of Patients Presenting With compLEX and Calcified Coronary Artery Disease
Completed	`NCT05112250` - IVL for Stent Underexpantsion
Not yet recruiting	`NCT06379295` - Coronary Artery Calcification Assessed on PET/CT
Completed	`NCT02913144` - 7 Year Follow-up Study of the DanRisk Population	N/A
Completed	`NCT00860847` - Firefighter Aged Garlic Extract Investigation With CoQ10 as a Treatment for Heart Disease (FAITH)	Phase 3
Not yet recruiting	`NCT04319666` - Intravascular Balloon Lithotripsy in Left Main Stem Percutaneous Coronary Intervention	N/A
Completed	`NCT03967366` - Melatonin and Coronary Artery Calcification
Recruiting	`NCT05818098` - Coronary Intravascular Lithotripsy System in Patients With Coronary Artery Calcification (VIGOUR)	N/A
Recruiting	`NCT05283538` - Comparison of Cardiovascular Risk Stratification in Young People With Type 1 Diabetes by Coronary Calcium Score to ESC/ESA2019 Recommendations	N/A
Recruiting	`NCT04742478` - ROVUS Asia Registry (Evaluate Safety and Effectiveness of Rotational Atherectomy and Intravascular Ultrasound for Heavily Calcified Coronary Lesion)
Recruiting	`NCT05259046` - The InterVitaminK Trial - Effects of Vitamin K Supplementation on Cardiovascular, Metabolic, and Bone Health	N/A
Recruiting	`NCT01101698` - Vitamin K2 and Vessel Calcification in Chronic Kidney Disease Patients	Phase 4