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Coronary Artery Bypass clinical trials

View clinical trials related to Coronary Artery Bypass.

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NCT ID: NCT02731794 Active, not recruiting - Clinical trials for Coronary Artery Bypass

On-pump Beating Coronary Artery Bypass Grafting by Ventricular Assist

Start date: May 2016
Phase: Phase 4
Study type: Interventional

The investigators designed the randomized prospective study to evaluate the differences of inflammatory response and clinical outcome after on-pump beating coronary artery bypass grafting undergoing left ventricular assist versus biventricular assist in patients with severe left ventricle dysfunction.

NCT ID: NCT02722213 Completed - Heart Failure Clinical Trials

Mindfulness & Stress Management Study for Cardiac Patients

Start date: May 2016
Phase: N/A
Study type: Interventional

The guideline-recommended standard of care for patients who have experienced a heart attack, heart failure, or other coronary event or procedure is exercise-based cardiac rehabilitation (CR). Despite proven benefits, traditional CR is severely underutilized. Moreover, what is typically lacking from traditional CR programs is effective psychosocial risk management. This represents a critical gap in care given the well-documented psychosocial needs of this patient population.The objective of this feasibility study is to conduct a pilot randomized controlled trial (RCT) of Mindfulness-Based Stress Reduction (MBSR) versus usual care in CR-eligible cardiac patients. Randomization will be stratified within two strata based on participation in CR (yes/no) among CR-eligible patients. The primary goals of this pilot study are to: 1) obtain estimates of treatment effects and variability; 2) evaluate recruitment and retention strategies; and 3) examine the safety of the MBSR protocol in CR-eligible patients.

NCT ID: NCT02678559 Completed - Clinical trials for Coronary Artery Disease

Preload Dependency Evaluation With Stroke Volume Variation During Alveolar Recruitment Manoeuvres

PreDeARM
Start date: February 2016
Phase: N/A
Study type: Interventional

The principal aim is to assess impact of alveolar recruitment manoeuvres (ARM) on stroke volume variation, evaluated by trans-oesophageal echocardiography (TEE). These variations will be measured on preload dependency or preload independency status. The principal purpose is to determine if variations of stroke volume during standardized ARM can predict the preload dependency status.

NCT ID: NCT02385344 Completed - Clinical trials for Coronary Artery Bypass

Registry for Quality Assessment With Ultrasound Imaging and TTFM in Cardiac Bypass Surgery

REQUEST
Start date: April 2015
Phase:
Study type: Observational [Patient Registry]

The purpose of the registry is to collect information regarding the number and type of coronary artery bypass (CAB) surgical procedure changes that are made based on intraoperative guidance information using transit time flow measurements (TTFM) and ultrasound image capabilities provided with the Medistim device.

NCT ID: NCT02352376 Completed - Clinical trials for Coronary Artery Bypass

Noninvasive Ventilation After Coronary Bypass Grafting

Physiotherapy
Start date: March 2013
Phase: Phase 4
Study type: Interventional

This is a prospective, quantitative, randomized, crossover study. Were included in this study 10 people in the Intensive Care Unit at University Hospital in Uberlandia, on the first day of the postoperative coronary artery bypass graft (CABG). For data collection was performed randomization on the block (2: 4), to determine the first technique to be used and then a wash-out period of one hour was allowed for the research subject reaches the systemic arterial pressure, heart rate, respiratory rate and oxygen saturation baseline. And after, for cross-over, the second technique was performed. Non-invasive ventilation was performed for 30 minutes each ventilator. All subjects underwent noninvasive ventilation using two models of ventilators, they are conventional (designed for invasive ventilation but is also used in non-invasive ventilation mode) and specific (designed for non-invasive ventilation). Hemodynamic, autonomic and respiratory variables are monitored. We use the hypothesis that non-invasive ventilation performed with two fan models can alter autonomic function and that there is hemodynamic changes related to autonomic function in different ventilators in postoperative coronary artery bypass grafting.

NCT ID: NCT02322892 Completed - Clinical trials for Coronary Artery Bypass

Thiamine as an Adjunctive Therapy in Cardiac Surgery

Start date: January 2015
Phase: Phase 2
Study type: Interventional

The main purpose of this pilot study is to test the effects of thiamine (vitamin B1) administration before and after major cardiac surgery. Half of patients will receive thiamine and the other half will receive placebo. The investigators' main hypothesis is that thiamine will improve cellular oxygen consumption and lead to decreased levels of post-operative lactate levels and ultimately improved patient outcomes.

NCT ID: NCT02307084 Terminated - Clinical trials for Surgical Wound Infection

Ultrasound to Prevent Leg Wound Complications in Heart Bypass.

Start date: February 2015
Phase: N/A
Study type: Interventional

The long saphenous vein is traditionally harvested for use as a conduit in coronary artery bypass grafting surgery. Currently, the long saphenous vein is not imaged prior to surgery. This study aims to evaluate preoperative ultrasound mapping of the long saphenous vein to to improve patient and clinical outcomes.

NCT ID: NCT02201771 Completed - Clinical trials for Coronary Artery Bypass

Different Antiplatelet Therapy Strategy After Coronary Artery Bypass Graft Surgery

DACAB
Start date: July 2014
Phase: Phase 4
Study type: Interventional

The study population will include all patients undergoing elective CABG. Consent and randomization will occur before surgery. Total 500 patients undergoing elective CABG will be randomly assigned into three groups with 1:1:1 ratio(167 patients per group) in this open-label study. All the enrolled patients will stop oral antiplatelet drugs according to local protocol before the surgery. Within the first 24 hours after surgery, study medication should be restarted and continued for 12 months. Arm A will restart oral antiplatelet drugs by giving aspirin 100mg qd, Arm B will also restart oral antiplatelet drugs by giving ticagrelor 90mg bid plus aspirin 100mg qd and Arm C will also restart oral antiplatelet drugs by giving ticagrelor 90mg bid. Treatment will continue for 12 months, at which time patients will undergo a multislice computed tomography angiography to assess vein graft patency. This study is designed to show the superiority of ticagrelor and ticagrelor plus aspirin as compared with aspirin monotherapy respectively for the 1-year primary efficacy end point of vein graft patency.

NCT ID: NCT01603589 Completed - Clinical trials for Coronary Artery Bypass

Comparison of Minimal Versus Conventional Extracorporeal Circulation in Coronary Surgery

Start date: January 2009
Phase: N/A
Study type: Interventional

The aim of this study is to assess the effect of minimal (MiECC) versus conventional (CECC) extracorporeal circulation on perfusion characteristics and remote end-organ protection (lungs, brain, kidneys, liver, stomach, intestine), after elective coronary bypass grafting (CABG).

NCT ID: NCT01560780 Completed - Clinical trials for Coronary Artery Bypass

Prasugrel for Prevention of Early Saphenous Vein Graft Thrombosis

Start date: February 1, 2013
Phase: Phase 3
Study type: Interventional

This is a randomized-controlled clinical trial that will randomize 120 patients undergoing clinically-indicated coronary artery bypass graft surgery to prasugrel at a dose of 10 mg daily or matching placebo for 12 months, starting at the time of hospital dismissal from surgery. The primary goal of the study is to determine whether prasugrel administration will prevent thrombus (clot) formation within a saphenous vein graft at 12 months, as examined by optical coherence tomography.