Coronary Artery Bypass Grafting Clinical Trial
— IRM-FAPOOfficial title:
Assessment of Atrial Cardiomyopathy Using MRI as a Predictor of Cardiac Post-Operative Atrial Fibrillation After Cardiac Surgery.
After cardiac surgery, there is a high prevalence of postoperative atrial fibrillation (POAF). However, its diagnostic and therapeutic management is poorly codified. This pathology is caused by atrial abnormalities which form the concept of atrial cardiomyopathy. New tools affording to itemize the atrial cardiomyopathy are needed. Indeed, current tools, as echocardiography and electrocardiogram are relevant but only lead to a raw evaluation of the atrial cardiomyopathy. MRI, because of the assessment of the atrial fibrosis by late gadolinium assessment (LGE) and 4D flow magnetic resonance imaging (MRI) could be relevant to specify the atrial cardiomyopathy.
Status | Not yet recruiting |
Enrollment | 88 |
Est. completion date | August 2026 |
Est. primary completion date | August 2026 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Age = 18 years - Indication for surgical myocardial revascularization by coronary artery bypass - Patient affiliated or entitled to a social security scheme - Informed consent for participation in the study Exclusion Criteria: - Contraindication to cardiac MRI (Severe Kidney disease, Allergy to gadoliniumn, ...) - History of Atriale Fibrillation (AF) - Indication of cardiac valve surgery concomitantly with Coronary Artery Bypass Grafting (CABG). - pregnant or breast-feeding women |
Country | Name | City | State |
---|---|---|---|
France | CHU Saint-Etienne | Saint-Étienne |
Lead Sponsor | Collaborator |
---|---|
Centre Hospitalier Universitaire de Saint Etienne |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Analysis of the occurrence of Post-Operative Atrial Fibrillation | Measured by a continuous recording of cardiac electrical activity during 7 days after the surgery. | 7 days after the surgery | |
Secondary | Analysis of the occurrence of Atrial Fibrillation | Analysis of the occurrence of Atrial Fibrillation evaluated during the first year post-operatively. | Year: 1 | |
Secondary | Anatomopathological parameters for the evaluation of tissue fibrosis | Analysis Anatomopathological parameters for the evaluation of tissue fibrosis evaluated by cardiac muscle biopsy. | Year: 1 | |
Secondary | Assessment of Atrial Heart Disease by cardiac Magnetic Resonance Imaging (MRI) results | Assessment of Atrial Heart Disease by cardiac Magnetic Resonance Imaging (MRI) results to find a correlation with Post-Operative Atrial Fibrillation. | Before the surgery | |
Secondary | Correlation between biological parameter Interleukin 1 (IL-1) and occurrence of Post-Operative Atrial Fibrillation | Measured by blood sample results. | Years: 2 | |
Secondary | Correlation between biological parameter TNF-a and occurrence of Post-Operative Atrial Fibrillation | Measured by blood sample results. | Years: 2 |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT04566497 -
Assessment of Adverse Outcome in Asymptomatic Patients With Prior Coronary Revascularization Who Have a Systematic Stress Testing Strategy Or a Non-testing Strategy During Long-term Follow-up.
|
N/A | |
Completed |
NCT01850082 -
Randomized Endo-Vein Graft Prospective
|
N/A | |
Completed |
NCT02889562 -
Apixaban Versus Warfarin for the Management of Post-operative Atrial Fibrillation
|
Phase 2/Phase 3 | |
Completed |
NCT01528514 -
Effects of CUrcuminoids on Coronary Artery byPass graftIng-related myocarDial Infarction Study
|
N/A | |
Completed |
NCT01378221 -
VItamin D Metabolism in SEnescent Cardiac Surgery Patients
|
N/A | |
Completed |
NCT00848796 -
Comparative Study of Two Brands of Heparin Already on the Market
|
N/A | |
Not yet recruiting |
NCT05552586 -
Melatonin Impact on the Outcomes of Myocardial Ischemia/Reperfusion Injury During Coronary Artery Bypass Grafting Surgery
|
N/A | |
Completed |
NCT00246740 -
Protection of the Heart With Doxycycline During Coronary Artery Bypass Grafting
|
Phase 2 | |
Completed |
NCT00420667 -
Low Molecular Weight Heparin vs Unfractionated Heparin at Cardiac Surgery
|
N/A | |
Recruiting |
NCT04197700 -
The PRESSURE CABG Cardiac Surgery Trial
|
N/A | |
Not yet recruiting |
NCT05835167 -
Complete Revascularization Via Inferior Part-sternotomy
|
N/A | |
Not yet recruiting |
NCT06326996 -
Thiamine Intervention and Coronary Artery Bypass Grafting
|
N/A | |
Not yet recruiting |
NCT02732574 -
Oscillating Positive Expiratory Pressure (OPEP) Therapy in High Risk Patients Following Cardiac Surgery
|
N/A | |
Completed |
NCT00903604 -
Pharmacokinetics of AP214 Acetate in Patients Undergoing Cardiac Surgery
|
Phase 2 | |
Completed |
NCT01182688 -
Prospective Review of Procalcitonin After Cardiac Surgery
|
N/A | |
Completed |
NCT02737215 -
Prevention of Atrial Fibrillation After Coronary Artery Bypass Grafting in Patients With Obstructive Sleep Apnea
|
N/A | |
Recruiting |
NCT03209414 -
Frailty Syndrome in Daily Practice of Interventional Cardiology Ward
|
||
Recruiting |
NCT05441358 -
Assessment of Platelet Function in Patients Undergoing Open Heart Surgery
|
||
Recruiting |
NCT02400125 -
China Cardiovascular Surgery Registry
|
N/A | |
Terminated |
NCT00628264 -
Safety, Tolerability and Pharmacodynamics of AP214 Acetate in Patients Undergoing Cardiac Surgery
|
Phase 2 |