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Corneal Diseases clinical trials

View clinical trials related to Corneal Diseases.

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NCT ID: NCT04484402 Completed - Corneal Disease Clinical Trials

Treatment of Patients With Inflammatory-dystrophic Diseases of the Cornea Using Autologous Stem Cells

Start date: October 3, 2016
Phase: Phase 1/Phase 2
Study type: Interventional

Treatment of patients with inflammatory-dystrophic diseases of the cornea using autologous limbal stem cells (corneal epithelial stem cells) or adipose-derived mesenchymal stem cells

NCT ID: NCT04475900 Completed - Glaucoma Clinical Trials

Computer-aided Diagnosis of Ocular Diseases Based on Corneal Biomechanics

EyeTwin
Start date: July 9, 2020
Phase:
Study type: Observational

The purpose of this study is the investigation of biomechanical properties of the cornea using computer-aided data analysis. Currently, it is known that keratoconus and glaucoma are ocular disease that are associated with biomechanical alterations of the cornea. Corneal ectasia, especially keratoconus, is a corneal disease that leads to an irreversible loss of visual acuity while the cornea becomes steeper, thinner and irregular. For these patients, surgical intervention (e.g. corneal cross-linking) is performed, in case of disease progression. In glaucoma, the information about corneal alterations serves in two ways, first, correct measurement of intra ocular pressure (IOP); second, early diagnosis of suspects before visual field defects are detectable. Especially, the Corvis ST is an air-puff tonometer that measures intraocular pressure, corneal thickness (CCT) as well as dynamic corneal response (DCR) parameters. Most of the DCR parameters are affected by IOP and CCT: Therefore, algorithm are needed to determine parameters without impact of IOP and CCT that are describe the biomechanical properties of the cornea.

NCT ID: NCT04447157 Completed - Microspherophakia Clinical Trials

The Efficacy of a 6-point Transscleral Suture Fixation of a 3-looped Haptics PC-IOL Implantation Through Scleral Pockets for Surgical Management for Microspherophakia

Start date: July 1, 2016
Phase:
Study type: Observational

By comparing the preoperative data and postoperative data of 9 patients of microspherophakia, we concluded that the 6-point transscleral suture fixation of a 3-looped haptics posterior chamber intraocular lens (PC-IOL) through scleral pockets was a feasible method of PC-IOL implantation in the surgical treatment of microspherophakia.

NCT ID: NCT04439552 Recruiting - Pain, Postoperative Clinical Trials

fMRI and IVCM Cornea Microscopy of CXL in Keratoconus

Start date: October 4, 2021
Phase:
Study type: Observational

Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).

NCT ID: NCT04421300 Completed - Dry Eye Clinical Trials

A Randomized Study of Smile Exercise for Dry Eye

Start date: July 2, 2020
Phase: N/A
Study type: Interventional

The objective of the study is to evaluate the effectiveness of laughter therapy in relieving the symptoms of dry eye disease.

NCT ID: NCT04318132 Completed - Glaucoma Clinical Trials

Agreement and Precision Study of the Nidek Mirante

Start date: January 25, 2020
Phase: N/A
Study type: Interventional

This study is a prospective comparative, randomized, single center study to gather agreement and precision of the Nidek Mirante OCT with SLO and Anterior Segment Imaging capabilities in comparison to the Optovue RTVue XR Avanti OCT and Optos P200DTx in normal subjects, subjects with glaucoma, subjects with retinal disease and subjects with corneal disease.

NCT ID: NCT04267991 Completed - Corneal Disease Clinical Trials

Corneal Densitometry Changes With Adenoviral SEI

Start date: April 1, 2018
Phase:
Study type: Observational

Adenoviral Sub epithelial infiltrates (SEI) affect ocular function.They lead to reduced vision, photophobia, glare, halos, and foreign body sensation.

NCT ID: NCT04251143 Recruiting - Keratoconus Clinical Trials

Dresden Corneal Disease and Treatment Study

Start date: March 12, 2018
Phase:
Study type: Observational

The purpose of this study is long-term follow up of patients with corneal diseases to analyze the quality of surgical interventions and diagnosis. Corneal ectasia, especially keratoconus, is a corneal disease that leads to an irreversible loss of visual acuity while the cornea becomes steeper, thinner and irregular. For these patients, surgical intervention (e.g. corneal cross-linking) is performed, in case of disease progression. Overall, a long-term follow up is needed to evaluate an early disease progression as well as corneal stability after surgical intervention.

NCT ID: NCT04164407 Recruiting - Keratoconus Clinical Trials

Keratoconus, Corneal Diseases and Transplant Registry

KCDTR
Start date: December 1, 2019
Phase:
Study type: Observational

The cornea is the clear layer in front of the iris and pupil. It protects the iris and lens and helps focus light on the retina. Corneal diseases are serious conditions that can cause clouding, distortion, scarring and eventually blindness. There are several types of corneal disease with keratoconus being one of the most prominent. Keratoconus is a weakening and thinning of the central cornea. This thinking causes the cornea to develop a cone-shaped deformity leading to vison loss. Keratoconus is usually bilateral affecting people between 10 and 25. This project aims to collect data on patient suffering with corneal diseases and the treatments they receive, including corneal transplantation, over a period of time during routine clinical practice. A clinical registry such as this can be a very useful tool to provide a real-world view of clinical practice, patient outcomes, safety, and comparative effectiveness. •Methods: Data will be collected from the medical records of patients who have suffered from corneal disease and have undergone treatment in the Ophthalmology department of the CHU Montpellier. A standardized set of data will be collected for all patients. This will include, demographic and social date such as lifestyle and occupation, current and past pathologies and treatment received. This is data that is already collected as part of routine clinical practice. This will be an ongoing registry with the aim of collecting the maximum data possible. The more patients that are entered and the longer the follow up for each patient, the more valuable the data will become. •Discussion: The aim of this registry to help create a better understanding of variations in treatment and outcomes; to examine factors that influence prognosis; to describe treatment patterns, including appropriateness and effectiveness of treatment and disparities in the delivery of care; to monitor safety and harm and to measure quality of care. In the long term the data collected in the registry may serve as a basis for the development of evidence-based clinical management guidelines to help clinicians deliver the most appropriate treatment for corneal diseases in the safest and most efficient manner.

NCT ID: NCT04130490 Completed - Cataract Clinical Trials

The Heidelberg Engineering ANTERION Anterior Segment Cornea and IOL Precision and Agreement Study

Start date: October 11, 2019
Phase:
Study type: Observational

This is a prospective clinical study that will be conducted at one clinical site located in the United States to assess anterior segment parameters with the ANTERION