Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
Evaluation of Skeletal Muscle Function in Patients With Chronic Obstructive Pulmonary Disease Before and After Lung Rehabilitation Training Using Ultrasonic Elastography
The goal of observational study is to evaluation of skeletal muscle function in patients with chronic obstructive pulmonary disease before and after lung rehabilitation training using ultrasonic elastography in Chronic Obstructive Pulmonary Disease. The main question it aims to answer are:Evaluation of skeletal muscle function in patients with chronic obstructive pulmonary disease before and after lung rehabilitation training using ultrasonic elastography. Participants will undergo pulmonary rehabilitation.
Status | Not yet recruiting |
Enrollment | 60 |
Est. completion date | December 31, 2024 |
Est. primary completion date | October 31, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 40 Years to 80 Years |
Eligibility | Inclusion Criteria: - The age is between 40-80 years old - Patients with chronic obstructive pulmonary disease who meet the diagnostic criteria of GOLD guideline(2019) - There was no acute exacerbation in the past 12 weeks Exclusion Criteria: - Hypoxemia (oxygen partial pressure is less than 60mmHg or oxygen saturation is less than 88% at rest), or patients who need continuous oxygen inhalation, or patients with any contraindication to exercise test (refer to the American Thoracic Association/American Association of Thoracic Physicians exercise test guidelines) - Oral glucocorticoids - Receive long-term oxygen therapy prescription - Have participated in supervised exercise programs in the past 12 months - History of other lung diseases, including pneumoconiosis, bronchiectasis, tuberculosis, primary pulmonary hypertension, pulmonary embolism, interstitial lung disease - Diseases that restrict the active exercise ability of participants or involve skeletal, neuromuscular, cardiovascular or metabolic disorders of muscle activity, such as tumors, diabetes, muscle weakness, etc |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
China-Japan Friendship Hospital |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Effectiveness of pulmonary rehabilitation training | 6-minute walking distance (6MWD) | baseline | |
Primary | Effectiveness of pulmonary rehabilitation training | 6-minute walking distance (6MWD) | 1 week after pulmonary rehabilitation | |
Primary | Effectiveness of pulmonary rehabilitation training | COPD Assessment Test (CAT) score | baseline | |
Primary | Effectiveness of pulmonary rehabilitation training | COPD Assessment Test (CAT) score | 1 week after pulmonary rehabilitation | |
Primary | Effectiveness of pulmonary rehabilitation training | St. George's Respiratory Questionnaire (SGRQ) | baseline | |
Primary | Effectiveness of pulmonary rehabilitation training | St. George's Respiratory Questionnaire (SGRQ) | 1 week after pulmonary rehabilitation | |
Primary | Effectiveness of pulmonary rehabilitation training | modified Medical Research Council (mMRC) dyspnea scores | baseline | |
Primary | Effectiveness of pulmonary rehabilitation training | modified Medical Research Council (mMRC) dyspnea scores | 1 week after pulmonary rehabilitation | |
Primary | Effectiveness of pulmonary rehabilitation training | rectus femoris muscle strength via a dynamometer | baseline | |
Primary | Effectiveness of pulmonary rehabilitation training | rectus femoris muscle strength via a dynamometer | 1 week after pulmonary rehabilitation | |
Primary | Effectiveness of pulmonary rehabilitation training | 6-30-second sit-to-stand test | baseline | |
Primary | Effectiveness of pulmonary rehabilitation training | 6-30-second sit-to-stand test | 1 week after pulmonary rehabilitation | |
Secondary | Forced Expiratory Volume in 1-second(FEV1) | Pulmonary function test | before pulmonary rehabilitation | |
Secondary | Forced Expiratory Volume in 1-second(FEV1) | Pulmonary function test | 1 week after pulmonary rehabilitation | |
Secondary | Ultrasonic elastic imaging of rectus femoris | Ultrasonic elastography of skeletal muscle | before pulmonary rehabilitation | |
Secondary | Ultrasonic elastic imaging of rectus femoris | Ultrasonic elastography of skeletal muscle | 1 week after pulmonary rehabilitation |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT05102305 -
A Multi-center,Prospective, OS to Evaluate the Effectiveness of 'NAC' Nebulizer Therapy in COPD (NEWEST)
|
||
Completed |
NCT01867762 -
An Effectiveness and Safety Study of Inhaled JNJ 49095397 (RV568) in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease
|
Phase 2 | |
Recruiting |
NCT05562037 -
Stepped Care vs Center-based Cardiopulmonary Rehabilitation for Older Frail Adults Living in Rural MA
|
N/A | |
Terminated |
NCT04921332 -
Bright Light Therapy for Depression Symptoms in Adults With Cystic Fibrosis (CF) and COPD
|
N/A | |
Completed |
NCT03089515 -
Small Airway Chronic Obstructive Disease Syndrome Following Exposure to WTC Dust
|
N/A | |
Completed |
NCT02787863 -
Clinical and Immunological Efficiency of Bacterial Vaccines at Adult Patients With Bronchopulmonary Pathology
|
Phase 4 | |
Recruiting |
NCT05552833 -
Pulmonary Adaptive Responses to HIIT in COPD
|
N/A | |
Recruiting |
NCT05835492 -
A Pragmatic Real-world Multicentre Observational Research Study to Explore the Clinical and Health Economic Impact of myCOPD
|
||
Recruiting |
NCT05631132 -
May Noninvasive Mechanical Ventilation (NIV) and/or Continuous Positive Airway Pressure (CPAP) Increase the Bronchoalveolar Lavage (BAL) Salvage in Patients With Pulmonary Diseases?
|
N/A | |
Completed |
NCT03244137 -
Effects of Pulmonary Rehabilitation on Cognitive Function in Patients With Severe to Very Severe Chronic Obstructive Pulmonary Disease
|
||
Not yet recruiting |
NCT03282526 -
Volume Parameters vs Flow Parameters in Assessment of Reversibility in Chronic Obstructive Pulmonary Disease
|
N/A | |
Completed |
NCT02546700 -
A Study to Evaluate Safety and Efficacy of Lebrikizumab in Participants With Chronic Obstructive Pulmonary Disease (COPD)
|
Phase 2 | |
Withdrawn |
NCT04446637 -
Acute Bronchodilator Effects of Ipratropium/Levosalbutamol 20/50 mcg Fixed Dose Combination vs Salbutamol 100 mcg Inhaler Plus Ipratropium 20 mcg Inhalation Aerosol Free Combination in Patients With Stable COPD
|
Phase 3 | |
Completed |
NCT04535986 -
A Phase 3 Clinical Trial to Evaluate the Safety and Efficacy of Ensifentrine in Patients With COPD
|
Phase 3 | |
Recruiting |
NCT05865184 -
Evaluation of Home-based Sensor System to Detect Health Decompensation in Elderly Patients With History of CHF or COPD
|
||
Completed |
NCT03295474 -
Telemonitoring in Pulmonary Rehabilitation: Feasibility and Acceptability of a Remote Pulse Oxymetry System.
|
||
Completed |
NCT03256695 -
Evaluate the Relationship Between Use of Albuterol Multidose Dry Powder Inhaler With an eModule (eMDPI) and Exacerbations in Participants With Chronic Obstructive Pulmonary Disease (COPD)
|
Phase 3 | |
Withdrawn |
NCT04042168 -
Implications of Appropriate Use of Inhalers in Chronic Obstructive Pulmonary Disease (COPD)
|
Phase 4 | |
Completed |
NCT03414541 -
Safety And Efficacy Study Of Orally Administered DS102 In Patients With Chronic Obstructive Pulmonary Disease
|
Phase 2 | |
Completed |
NCT02552160 -
DETECT-Register DocumEnTation and Evaluation of a COPD Combination Therapy
|