Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
Assessment of Reactance Parameters Measured by the Forced Oscillation Technique for the Bronchodilator Response in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
Verified date | April 2019 |
Source | Centre Hospitalier Universitaire Dinant Godinne - UCL Namur |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The aims of this study is :
- to assess the bronchodilator (DUOVENT HFA) response of parameters measured by the forced
oscillations (FOT) and in particular the reactance parameters related to the presence of
a limitation of expiratory flows
- to compare the response of the reactance parameters to bronchodilators with the
conventional spirometric parameters (FEV1) and inspiratory capacity (IC), and according
to the severity of the disease
- to assess and compare the relationship between the response to bronchodilators in terms
of IC on the one hand and on the other hand in terms of FEV1, reactance parameters
(measured by FOT), resistance parameters (measured by plethysmography and FOT)
- Assess and compare the relationship between dyspnea intensity assessed by various scales
and conventional respiratory function parameters (spirometry, plethysmography, diffusion
indices) and parameters measured by FOT
Status | Not yet recruiting |
Enrollment | 80 |
Est. completion date | December 31, 2021 |
Est. primary completion date | December 31, 2021 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 40 Years and older |
Eligibility |
Inclusion Criteria: - Clinical diagnosis of COPD confirmed by post-bronchodilator (DUOVENT HFA 4 puffs) obstructive airway obstruction (FEV1/Forced Vital Capacity < Percentile 5) persisting after bronchodilatation - Former or active smoking > 10 packs/year - Age > 40 years - Informed consent Exclusion Criteria: - Inability to comply with bronchodilator weaning time : 6 hours for short-acting bronchodilators ; 12 hours for long-acting bronchodilators ; 24 hours for very long-acting bronchodilators - Inability to comply with the 4 hours of smoking cessation before the measurements - Inability to perform respiratory function tests - Continuous oxygen therapy - Close angle glaucoma - History of urinary retention (only for patients not usually treated with anticholinergic bronchodilators) - Pregnancy - Acute illness contraindicating the performance of respiratory tests |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Centre Hospitalier Universitaire Dinant Godinne - UCL Namur |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Acute inspiratory capacity increase | 30 minutes |
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