Air Pollution and COPD Exacerbation

Chronic Obstructive Pulmonary Disease Clinical Trial

— BePoPi  

Official title:

Impact of Air Pollution on Chronic Obstructive Pulmonary Disease (COPD) Exacerbation in Haut de France. BePoPi Project.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03904875
• Other study ID #: PI2019_843_0008
• Status: Completed
• Start date: January 1, 2020
• Est. completion date: September 12, 2023

Study information

• Verified date: September 2023
• Source: Centre Hospitalier Universitaire, Amiens
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

There is an excess of hospitalization rates for acute exacerbation of COPD in Picardy compared to the national data. A first study realized in Picardy has shown a link between air quality and COPD. Nevertheless, the particles type is unknown and according to it, impact on COPD could be different. The investigator goal is to find a correlation between acute exacerbation of COPD consultation rate and daily ultra thin particles in Haut de France. The investigators will correlate the particles composition with daily acute exacerbation of COPD rate. All COPD patients with a diagnosis of acute exacerbation in emergency room in University Hospital of Amiens-Picardie and Lille, and Clinique de l'Europe between 01/01/2020 and 31/12/2020 will be included. For each patient, home and work address will be collected. The duration of 1 year was chosen to take into account seasonal variations. In parallel, a daily report of the rate of ozone, particles (PM2.5 and PM10), dioxide nitrogen but also odours and pollens will be done by ATMO Haut de France.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 120
• Est. completion date: September 12, 2023
• Est. primary completion date: March 12, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• COPD patients with a diagnosis of acute exacerbation of COPD in the emergency room of Amiens and Lille centers

• Adults

• Patients able to express consent

• signed written informed consent form

• covered by national health insurance

Exclusion Criteria:

• patients non covered by national health insurance

• patients not able to express consent

• minors

Related Conditions & MeSH terms

• Chronic Obstructive Pulmonary Disease
• Lung Diseases
• Lung Diseases, Obstructive
• Pollution; Exposure
• Pulmonary Disease, Chronic Obstructive

Intervention

Other:
• collection of data about each acute exacerbation of COPD
COPD is chronic obstructive pulmonary disease. Data collected are need of hospitalisation, final diagnosis, home address, work address and air quality data.

Locations

Country	Name	City	State
France	CHU Amiens	Amiens

Sponsors (3)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire, Amiens	Clinique de l'Europe, Amiens, University Hospital, Lille

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	daily rate of COPD exacerbation consultation in the emergency room of the 3 centers	daily rate of COPD exacerbation consultation in the emergency room of the 3 centers	every day during 12 months
Primary	ultrathin particles quantity in the air	ultrathin particles quantity will be determined by the air of "Haut de France" by the company ATMO Haut de France.	every day during 12 months
Secondary	chemical composition ultrathin particles	chemical composition ultrathin particles will be determined by the air of "Haut de France" by the company ATMO Haut de France.	every day during 12 months