Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
Endoscopic Long Volume Reduction by Endobronchial Valves in Belgium
This a single center non-randomised non-sham controlled intervention study evaluating the effectiveness and safety of endoscopic lung volume reduction by endobronchial valves
The primary objective of the current study is to explore the effect of targeted lobar
endobronchial lung volume reduction in symptomatic patients with severe emphysema and absent
collateral ventilation, on lung function, exercise capacity and physical activity. As a
secondary objective, changes in physical activity as result of a 3 month activity coaching
program delivered between 3 to 6 months post intervention will be investigated. Exploratory
objectives are to extend insight in the clinical characteristics of responders and
non-responders and to address relationships between lung function response, physical
functioning and its impact on inflammation, skeletal and cardiac function. Furthermore,
comparison of the effects on lung function, exercise capacity, quality of life and physical
activity between endoscopic lung volume reduction and surgical lung volume reduction will be
made.
The study will also explore if treatment response can be optimised by an intermediate
evaluation with CT scan one month after intervention. Endoscopic evaluation and repositioning
of the endobronchial valves will be imposed in case no lober atelectasis is visualised.
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