Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
Effects of Supplemental Oxygen Delivered by a Portable Oxygen Concentrator Compared to a Liquid Oxygen Device in Hypoxemic COPD Patients at Rest
The aim of this study is to investigate the effects of supplemental oxygen on blood oxygenation at rest in Patients with severe to very severe COPD comparing the portable oxygen concentrator (Activox™ 4L) to a liquid continuous oxygen device (Companion®).
It has been proven that supplemental oxygen increases oxygen saturation and reduces dyspnea
in hypoxemic COPD Patients. There are different oxygen delivery systems available, some of
them operating with liquid oxygen and others by concentrating the ambient air
(concentrators). An advantage of the concentrator system is, that there is no refill
required, but only a power plug and plug socket, enabling the patient for higher mobility and
to be more autonomous. There are only few publications about whether portable oxygen
concentrators have a comparable efficiency on oxygen saturation to liquid oxygen devices with
continuous flow (LOD) or not. Until now there are no official recommendations about how to
convert the oxygen flow rate for LOD (liter per minute) into the corresponding level of the
POC.
Therefore, we investigate the comparability of the portable oxygen concentrator Activox™ 4L
(POC) to a liquid oxygen device (Companion®) in 30 hypoxemic COPD patients at rest.
As a baseline assessment, the patients will receive a bodyplethysmography, blood gas analysis
without using supplemental oxygen and an evaluation of the diffusion capacity of the lung for
CO.
The study will be conducted on 2 consecutive days. 15 patients will be randomized into two
different groups: First group will start with POC and will continue the following day with
LOD; The second group will start with LOD and continue with POC (cross-over design). All
patients will use the same oxygen devices during the study assessments (LOD: Companion 1000
(CE 0050), Chart Industries Inc., Garfiel Heights, OH, USA; POC: Activox™ 4L, Inovalabs Inc.,
Texas, USA). On both days of the study, patients will be connected to one of the two systems
via nasal cannula for a total time period of 40 minutes, while the patient remains in a
sitting position without talking. The oxygen flow rate starts at 1liter/min (LOD) or Level 1
(POC) and will be increased every 10 minutes to the next higher level until the maximum of
4l/min (LOD) or level 4 (POC) is reached. Blood gases were taken and breathing frequency will
be recorded at the end of each Oxygen Level.
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