Beetroot Juice - Effects on Performance in Chronic Obstructive Pulmonary Disease Patients

Chronic Obstructive Pulmonary Disease Moderate Clinical Trial

— COPD  

Official title:

Beetroot Juice - Effects on Performance in Chronic Obstructive Pulmonary Disease Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03020862
• Other study ID #: D2013A2014
• Status: Completed
• Phase: N/A
• First received: January 11, 2017
• Last updated: January 13, 2017
• Start date: December 2013
• Est. completion date: August 2015

Study information

• Verified date: June 2014
• Source: University of Aarhus
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose is to evaluate exercise performance in patients with Chronic Obstructive Pulmonary Disease (COPD) after supplementing with higher doses of dietary NO3-, compared to previous studies, as beetroot juice for seven days. The secondary purpose is to evaluate oxygen consumption of submaximal cycling, amendments in blood pressure, and physical activity level.

Description:

The purpose is to evaluate exercise performance in patients with Chronic Obstructive Pulmonary Disease (COPD) using the 6-minute walk test (6MWT) after supplementing with higher doses of dietary NO3- compared to previous studies, as beetroot juice for seven days. The secondary purpose is to evaluate oxygen consumption of submaximal cycling, amendments in blood pressure, and physical activity level.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 15
• Est. completion date: August 2015
• Est. primary completion date: April 2014
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Moderate-severe Chronics Obstructive Pulmonary Disease (COPD) (FEV1 <80% of predicted).

Exclusion Criteria:

• Smoking,

• failure to complete physical testing,

• on-going participation in rehabilitation programs,

• pacemaker or use of nicotine products,

• oxygen mask,

• beta blockers,

• antibacterial mouthwash,

• chewing gum or stomach-neutralizing medicine during the intervention.

Related Conditions & MeSH terms

• Chronic Obstructive Pulmonary Disease Moderate
• Lung Diseases
• Lung Diseases, Obstructive
• Pulmonary Disease, Chronic Obstructive

Intervention

Dietary Supplement:
• Dietary beetroot juice
Consumed as concentrated beetroot juice from James White Drinks England (Beet-it) and contained 300 mg dietary nitrate. Dose: 2x70 mL consumed twice a day for six days.

Locations

Country	Name	City	State
Denmark	Sport Science, Department of Public Health, Aarhus University	Aarhus

Sponsors (1)

Lead Sponsor	Collaborator
University of Aarhus

Country where clinical trial is conducted

Denmark, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Physical performance on 6-min walk test (6MWT)		6 minutes
Secondary	Blood Pressure		At baseline and 150 minutes after consumption of beverages
Secondary	Plasma Nitrite concentration		Baseline, 150 and 210 minutes after consumption of beverages
Secondary	Oxygen consumption during submaximal cycling		Two trials of 6 minutes duration (10 min break between trials)
Secondary	Physical activity level	Measured all intervention days except on the day of testing	Six days