Cardiovascular Risk and Chronic Obstructive Pulmonary Disease — ECO-COPD  

Chronic Obstructive Pulmonary Disease Clinical Trial

Official title: Cardiovascular Risk and Chronic Obstructive Pulmonary Disease (COPD)

Status Recruiting

Clinical Trial Summary

The principal objective of the study is to measure parameters of inflammation, oxidative stress, and vascular, respiratory, and peripheral muscle function parameters, and identify parameters indicative of evolving cardiovascular risk (CVR) in COPD patients, using multivariate analysis.

Clinical Trial Description

Reduced lung function is a major risk factor for cardiovascular mortality (CV), regardless of age, sex and history of smoking. Similarly, CV events are known causes of mortality in patients with chronic obstructive pulmonary disease (COPD). The investigators propose to determine the parameters influencing the evolution of CV risk in a cohort of COPD patients followed over 5 years. For this the investigators will study the role of inflammation, oxidative stress, and vascular, respiratory and peripheral muscle function parameters.

In order to study a sufficient number of patients the investigators propose to group data from two cohorts: a first cohort of 121 COPD patients that already exists (currently closed to inclusions but still undergoing follow-up (NCT00404430)) and a new cohort of 150, decompensated or not, COPD patients.

This study is of major scientific interest and will enable to obtain extremely important information to better understand COPD. ;

Related Conditions & MeSH terms

• Chronic Obstructive Pulmonary Disease
• Lung Diseases
• Lung Diseases, Obstructive
• Pulmonary Disease, Chronic Obstructive

• NCT number: NCT03014609
• Study type: Observational [Patient Registry]
• Source: University Hospital, Grenoble
• Contact: Jean-Louis PEPIN, ProfessorPHD
• Phone: +33 476 768 473
• Email: JPepin@chu-grenoble.fr
• Status: Recruiting
• Start date: January 9, 2017
• Completion date: December 2029