COPD Clinical Trial
— EPITHREGENCOPDOfficial title:
Regeneration of Bronchial Epithelium During Chronic Obstructive Pulmonary Disease
Airway epithelium integrity is essential to maintain its role of mechanical and functional barrier. Recurrent epithelial injuries require a complex mechanism of repair to restore its integrity. In chronic obstructive pulmonary disease (COPD), an abnormal airway epithelial repair may participate in airway remodelling. The objective was to determine if airway epithelial wound repair of airway epithelium is abnormal in COPD.
Status | Completed |
Enrollment | 25 |
Est. completion date | May 2014 |
Est. primary completion date | December 2013 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 40 Years and older |
Eligibility |
Inclusion Criteria: 6 Patients scheduled for lung resection for cancer Exclusion Criteria: - Patients with asthma, cystic fibrosis, bronchiectasis or pulmonary fibrosis were excluded |
Observational Model: Case Control, Time Perspective: Cross-Sectional
Country | Name | City | State |
---|---|---|---|
France | Chu de Reims | Reims |
Lead Sponsor | Collaborator |
---|---|
CHU de Reims |
France,
Perotin JM, Adam D, Vella-Boucaud J, Delepine G, Sandu S, Jonvel AC, Prevost A, Berthiot G, Pison C, Lebargy F, Birembaut P, Coraux C, Deslee G. Delay of airway epithelial wound repair in COPD is associated with airflow obstruction severity. Respir Res. 2014 Nov 27;15:151. doi: 10.1186/s12931-014-0151-9. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Mean speed of wound closure (MSWC) of wounded bronchial epithelial cell culture obtained from COPD and control patients | hour 18 | No | |
Secondary | Cell proliferation index in supernatants of bronchial epithelial cells 18 hours after cell wounding. | hour 18 | No | |
Secondary | Matrix metalloprotease (MMP)-2 level in supernatants of bronchial epithelial cells 18 hours after cell wounding. | hour 18 | No | |
Secondary | Matrix metalloprotease (MMP)-9 level in supernatants of bronchial epithelial cells 18 hours after cell wounding. | hour 18 | No | |
Secondary | Cytokines levels in supernatants of bronchial epithelial cells 18 hours after cell wounding. | hour 18 | No |
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