Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
A Novel Individualized Resistance Training Program to Prehabilitate Patients With Chronic Obstructive Pulmonary Disease
NCT number | NCT02860728 |
Other study ID # | H16-01019 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | August 2016 |
Est. completion date | February 2020 |
Verified date | June 2022 |
Source | University of British Columbia |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Structural changes in skeletal muscles of patients with chronic obstructive pulmonary disease (COPD) have been linked to impaired muscle function, reduced exercise capacity, and increased mortality associated with this disease. Muscle dysfunction also contributes to dyspnea intensity and the ability to sustain exercise, making aerobic exercise training intolerable at the intensity and/or volume required to achieve clinically important changes. Resistance training (RT) is an attractive exercise modality because it is efficacious and more tolerable initially. No work has examined whether a short-term RT program can reduce exertional symptoms and improve exercise tolerance (dyspnea and leg fatigue) in patients with COPD.
Status | Completed |
Enrollment | 25 |
Est. completion date | February 2020 |
Est. primary completion date | February 2020 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 40 Years and older |
Eligibility | Inclusion Criteria: - Non-smokers >6 months - FEV1/FVC <0.7 and lower limit of normal - 30%< FEV1 pred <70% - Stable (no exacerbation for >3 months) Exclusion Criteria: - Cardiovascular and cerebrovascular disease - Diabetes - Cardiovascular contraindications to exercise - Uncontrolled hypertension - Currently performing regular structured exercise >3x/week for 30 minutes |
Country | Name | City | State |
---|---|---|---|
Canada | University of British Columbia | Kelowna | British Columbia |
Lead Sponsor | Collaborator |
---|---|
University of British Columbia |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Dyspnea | The change in the sensory intensity of dyspnea measured at an iso-time during the constant load exercise trials post RT | Baseline and post 4 weeks (12 sessions) of resistance training | |
Secondary | Exercise Tolerance | The change in the time to exhaustion during constant load exercise on a stationary cycle ergometer. | Baseline and post 4 weeks (12 sessions) of resistance training | |
Secondary | Secondary Dyspnea Outcomes | The change in the unpleasantness and sensory qualities of dyspnea measured at an iso-time during the constant load exercise trials post RT | Baseline and post 4 weeks (12 sessions) of resistance training | |
Secondary | Quadriceps Fatigue | Change in the amount of decline in force production after 3 minutes of electrical stimulation of femoral nerve at 25% of maximal voluntary contraction | Baseline and post 4 weeks (12 sessions) of resistance training | |
Secondary | Muscle Strength and Endurance | The change in 6RM quadriceps muscle strength and quadricep muscle endurance at 50% of predicted 1 RM | Baseline and post 4 weeks (12 sessions) of resistance training |
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