Chronic Obstructive Pulmonary Disease (COPD) Clinical Trial
Official title:
Oral β-Alanine Supplementation in Patients With COPD: Structural, Metabolic and Functional Adaptations
Preliminary evidence suggest that patients with chronic obstructive pulmonary disease (COPD)
suffer from lower-limb muscle dysfunction. This may, at least in part, be due to a
combination of physical inactivity and muscle oxidative stress. Pilot data (not published)
clearly show that patients with COPD have significantly lower carnosine, which is a pH
(acidity-basicity level) buffer and antioxidant, levels in the m. vastus lateralis compared
to healthy subjects. Beta-alanine supplementation has shown to increase muscle carnosine in
trained and untrained healthy subjects. This study will assess if muscle carnosine can be
augmented by beta-alanine supplementation in 40 COPD patients (20 patients receive
beta-alanine, 20 patients receive placebo). 10 healthy elderly controls will also be assessed
to compare baseline muscle carnosine levels.
The aims of this study are to:
1. Investigate baseline muscle carnosine levels to confirm the pilot data in a larger
sample of patients with COPD compared with healthy elderly subjects
2. Investigate if beta-alanine supplementation augments muscle carnosine in COPD patients
and whether it has an influence on exercise capacity, lower-limb muscle function and
quality of life
3. To investigate baseline and post supplementation structural and metabolic muscle
characteristics and markers of oxidative stress and inflammation in COPD patients and
it's association with muscle carnosine levels
n/a
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