Chronic Obstructive Pulmonary Disease (COPD) Clinical Trial
The purpose of this study is to determine the MRI characteristics of Chronic Obstructive
Pulmonary Disease subjects both at baseline and yearly for a period of 5 years, and to
correlate these biomarkers with pulmonary function tests, CT scan, 6 Minute-walk tests, and
respiratory questionnaires.
The central hypothesis is that quantitative assessment of the lung through magnetic
resonance imaging of hyperpolarized 3He can detect early alterations in structure and
function which are precursors to clinically apparent COPD and that these precursors can be
used to predict progression of disease earlier and better than established clinical methods.
Novel assessments using 3He MRI will lead to new information about COPD and will be critical
for characterizing disease response to therapy. A secondary hypothesis is that a variety of
technical improvements in the techniques of hyperpolarized gas MRI will accelerate the
translation of this relatively new modality to clinical use.
n/a
Observational Model: Case Control, Time Perspective: Prospective
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