Chronic Obstructive Pulmonary Disease (COPD) Clinical Trial
Official title:
Chronic Obstructive Pulmonary Disease (COPD) Lung Volume and Symptom Scores Following Bronchodilator Therapy Administration by Vibrating Mesh and Standard Jet Nebulisers: A Pilot Comparison Study
Treatment of chronic obstructive pulmonary disease (COPD) incorporates various modes of
inhalation therapy. The response to treatments is dose dependent thus applying the most
efficient device to administer the treatment is integral. Evaluation of the efficacy of
nebulisation devices in the treatment of COPD is limited. Technological development in recent
years has led to new devices that optimize lung deposition and reduce the time needed for
treatment.
The aim of this study is to compare the vibrating mesh and jet nebuliser methods of
delivering bronchodilator medication to patients hospitalised with an acute exacerbation of
COPD, with respect to lung function and efficacy in spontaneously breathing patients.
Treatment of chronic obstructive pulmonary disease (COPD) incorporates various modes of
inhalation therapy. The response to treatments is dose dependent thus applying the most
efficient device to administer the treatment is integral. Evaluation of the efficacy of
nebulisation devices in the treatment of COPD is limited. Technological development in recent
years has led to new devices that optimize lung deposition and reduce the time needed for
treatment.
The aim of this study is to compare the vibrating mesh and jet nebuliser methods of
delivering bronchodilator medication to patients hospitalised with an acute exacerbation of
COPD, with respect to lung function and efficacy in spontaneously breathing patients.
Patients admitted to hospital with an exacerbation of COPD and prescribed regular nebulised
bronchodilators (combined salbutamol 2.5mg and ipratropium 0.5mg) will be recruited to the
study. On one occasion between day 3-7 of admission they will perform pulmonary function
testing namely measurement of Forced Expiratory Volume in 1 second(FEV1), Forced Vital
Capacity (FVC), Inspiratory Capacity (IC) and cough peak flow. They will also complete the
Borg breathlessness score. Measurements will be recorded at baseline (pre-bronchodilator
administration) and one hour post-nebulised bronchodilator.
Patients will be randomised to receive their nebulised bronchodilators via the standard
hospital jet nebuliser or via a vibrating mesh nebuliser(Aerogen Solo).
Change in lung function and symptom measures between baseline and one-hour post nebulisation
will be analysed to look for any significant difference between the two groups
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