Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
Location and Timing of Inhaler Use, Exacerbations and Physical Activity in Chronic Obstructive Pulmonary Disease
This was an observational pilot study to examine the usefulness of an electronic sensor that monitors short-acting beta-agonist inhaled medication use. The goals of this study were to: 1) test the feasibility of using the inhaler sensor to measure worsening symptoms and exacerbations, 2) characterize physical activity in patients with COPD, and 3) examine whether environmental factors can be linked to mild exacerbations measured by the inhaler sensor.
Objectives: This study tested the usefulness of a GPS-enabled inhaler to study the
associations between air pollution, chronic obstructive pulmonary disease (COPD)
exacerbations, and physical activity. Specific aims are 1) test the feasibility of using the
inhaler sensor to measure worsening symptoms and exacerbations, 2) characterize physical
activity in patients with COPD, and 3) examine whether environmental factors can be linked
to mild exacerbations measured by the inhaler sensor.
Research Design: A 12-week observational, longitudinal pilot study of patients with COPD.
Methodology: Participants recruited at VA Puget Sound performed spirometry and completed
baseline questionnaires. An inhaler sensor was placed on their albuterol inhaler to record
the time and location of inhaler actuation throughout the three month follow-up. Each month
participants answered questions regarding their breathing symptoms and physical activity.
Physical activity was measured by self-report using a weeklong Physical Activity Checklist.
A pedometer was worn at three 7 day periods. Public use air pollution and meteorological
data will be linked to the inhaler data. We will compute descriptive statistics for all
measures, including sociodemographics, exacerbation rates, inhaler use, air pollution
exposures and physical activity levels. In addition, a time series analysis will be used to
test if the frequency of inhaler use is associated with higher levels of daily air
pollution.
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Observational Model: Cohort, Time Perspective: Prospective
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