Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
An Open-label, Non-Randomized, Multi-center Study to Assess the Safety and Effects of Intravenous Implantation of Liposuction Derived Autologous Adipose-derived Stem Cells in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
Verified date | July 2017 |
Source | Kimera Society Inc |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This will be an open-label, non-randomized multi-center study designed to assess the safety and efficacy of Adipose-derived Stem Cell (ASC) IV implantation. The therapy is composed of cells isolated from a patient's own adipose tissue. Liposuction will be performed to collect the adipose tissue specimen for subsequent processing to isolate the stem cells.
Status | Completed |
Enrollment | 26 |
Est. completion date | July 2017 |
Est. primary completion date | July 2017 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 85 Years |
Eligibility |
Inclusion Criteria: - Age 18 to 85, inclusive - A prior diagnosis of moderate to severe COPD - GOLD IIa, III, IV Exclusion Criteria: - Pregnant or lactating - Life expectancy < 6 months due to concomitant illnesses. - Exposure to any investigational drug or procedure within 1 month prior to study entry or enrolled in a concurrent study that may confound results of this study. - Any illness which, in the Investigators judgment, will interfere with the patient's ability to comply with the protocol, compromise patient safety, or interfere with the interpretation of study results - Subjects on chronic immunosuppressive or chemotherapeutic therapy - Known drug or alcohol dependence or any other factors which will interfere with the study conduct or interpretation of the results or who in the opinion of the investigator are not suitable to participate. - Subjects with Alpha-1 antitrypsin deficiency (an inherited disorder that can cause lung disease and liver disease). - Unwilling and/or not able to give written consent - Patient is positive for hepatitis (past history of Hepatitis A is allowed) - Any medical condition, which in the opinion of the clinical investigator, would interfere with the treatment or outcome of the patient - Cerebral aneurysm clips |
Country | Name | City | State |
---|---|---|---|
United States | Chicago | Chicago | Illinois |
United States | Dallas | Dallas | Texas |
United States | Melvin Propis M.D. | Davie | Florida |
United States | Las Vegas | Las Vegas | Nevada |
United States | New York | New York | New York |
Lead Sponsor | Collaborator |
---|---|
Kimera Society Inc |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | FEV1 Decline | The primary efficacy outcome will be a FEV1 decline of approximately or less than 30 ml at 12 month follow-up. | 12 months | |
Primary | Number of Adverse Events | 12 months | ||
Secondary | Secondary Efficacy Objective | The secondary efficacy objective will be a decrease in six minute walking distance (6MWD) of less than 5% over one year. | 12 Months |
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