Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
Inhaled Corticosteroids do Not Modify the Systemic Inflammation Induced by Exercise in Patients With Chronic Obstructive Pulmonary Disease
Verified date | August 2014 |
Source | Hospital Son Llatzer |
Contact | n/a |
Is FDA regulated | No |
Health authority | Spain: Ethics Committee |
Study type | Interventional |
Chronic obstructive pulmonary disease (COPD) is characterized by pulmonary and systemic inflammation. The effect of inhaled corticosteroids (IC) on inflammation in COPD is controversial.
Status | Completed |
Enrollment | 23 |
Est. completion date | November 2009 |
Est. primary completion date | November 2009 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 58 Years to 72 Years |
Eligibility |
Inclusion Criteria: - ex-smokers (> 10 packets-year) with moderate-severe COPD patients |
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Spain | Hospital Son Llatzer | Palma de Mallorca | Baleares |
Lead Sponsor | Collaborator |
---|---|
Hospital Son Llatzer | Fundació d'investigació Sanitària de les Illes Balears, Hospital Clinic of Barcelona, Hospital Son Espases, Sociedad Española de Neumología y Cirugía Torácica, Spanish Research Center for Respiratory Diseases |
Spain,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Differences in response to exercise between healthy and COPD patients | 16 COPD patients were compared with 7 healthy, sedentary and nonsmoker controls. All of them carried out an incremental cycle exercise test (ICET) limited by symptoms. 1 month later, ICET was repeated only by COPD patients. Venous blood samples were obtained at rest and during peak exercise. Anthropometric, functional and response characteristics to exercise: Age, years BMI, m2.kg-1 FEV1/FVC, % FEV1, % reference Peak charge, watts VO2 peak, mL.min-1 Respiratory quotient VE peak, L.min-1 Fc peak, lpm Lactic acid peak, mmol.L-1 SaO2 basal, % SaO2 peak, % |
1 month | No |
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