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NCT01715337 Clinical Trial

Effects of Rehabilitation on Muscle Fibre Composition and Capillaries in Chronic Obstructive Pulmonary Disease (COPD) Patients

Chronic Obstructive Pulmonary Disease Clinical Trial

Official title:
Effects of Pulmonary Rehabilitation on Muscle Fibre Composition and Capillaries in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01715337
Other study ID # COPD muscle 2011
Secondary ID
Status Completed
Phase N/A
First received October 24, 2012
Last updated April 14, 2014
Start date February 2010
Est. completion date April 2014

Study information
Verified date April 2014
Source Klinikum Berchtesgadener Land der Schön-Kliniken
Contact n/a
Is FDA regulated No
Health authority Germany: Ethics Commission
Study type Interventional

Clinical Trial Summary

Pulmonary rehabilitation has been established as an evidence-based and recommended therapy in patients with chronic obstructive pulmonary disease (COPD). The aim of our study is to show a potential change in muscle fibre composition and in the amount of capillaries in quadriceps muscle from pre tob post 3-week rehabilitation. Pulmonary rehabilitation includes standardised exercise training, e.g. cycling and strength training for major muscle groups.

Recruitment information / eligibility
Status Completed
Enrollment 20
Est. completion date April 2014
Est. primary completion date March 2013
Accepts healthy volunteers No
Gender Both
Age group 40 Years to 75 Years
Eligibility Inclusion Criteria:

- chronic obstructive pulmonary disease

- FEV1%pred. < 50%

Exclusion Criteria:

- acute exacerbation

- exacerbation in the last 4 weeks

Study Design

Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

Intervention

Other:
• pulmonary rehabilitation
3-week rehabilitation including exercise training, breathing therapy, psychosocial support, medical treatment etc.

Locations
Country Name City State
Germany Schön Klinik Berchtesgadener Land Schönau am Königssee

Sponsors (2)
Lead Sponsor Collaborator
Klinikum Berchtesgadener Land der Schön-Kliniken German Sport University, Cologne

Country where clinical trial is conducted

Germany, 

Outcome
Type Measure Description Time frame Safety issue
Primary Change in the amount of capillaries in muscle fibre type I change from pre (day 1) to post rehabilitation (day 21) Yes
Secondary Change in the amount of capillaries in muscle fibre type IIa Change from pre (day 1) to post rehabilitation (day 21) No
Secondary Change in the cross-sectional area of muscle fibre type I Change from pre (day 1) to post rehabilitation (day 21) No
Secondary Change in the cross-sectional area of muscle fibre type IIa Change from pre (day 1) to post rehabilitation (day 21) No
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