Chronic Obstructive Pulmonary Disease Clinical Trial
— SIMOfficial title:
Signaling Pathway Activation in the Quadriceps of Patients With COPD After an Acute Bout of Resistance
Verified date | May 2013 |
Source | Laval University |
Contact | n/a |
Is FDA regulated | No |
Health authority | Canada: Ethics Review Committee |
Study type | Interventional |
Muscle weakness and atrophy are important consequences of chronic obstructive pulmonary
disease (COPD). Although resistance exercises increase strength and muscle mass in patients
with COPD, the response to training appears to be suboptimal in these individuals. A
dysregulation in the signaling pathways involved in the regulation of muscle mass could play
an important role in this phenomenon.
Hypothesis: Proteins involved in muscle mass regulation will be less activated in the
quadriceps of patients with COPD following the acute bout of resistance training exercise
compared to healthy age-matched controls.
Status | Completed |
Enrollment | 21 |
Est. completion date | April 2013 |
Est. primary completion date | April 2013 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 50 Years to 75 Years |
Eligibility |
Inclusion Criteria: - Male - COPD with an FEV1 of under 60% of predicted - non-smoker - Between 50 and 75 years old Exclusion Criteria: - All inflammatory disease (HIV, Cancer, renal and cardiac deficiency) - Hormonal dysregulation - Inferior limb pathology - Neuromuscular pathology - History of tabacco or alcool abuse - Oxygen dependent - Recent exacerbation (2 months) of the symptoms of COPD |
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
Country | Name | City | State |
---|---|---|---|
Canada | IUCPQ | Quebec City | Quebec |
Lead Sponsor | Collaborator |
---|---|
Laval University | Canadian Institutes of Health Research (CIHR) |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Post-exercise signaling proteins phosphorylation level in the quadriceps of COPD patients and age-matched healthy controls | Phosphorylation status of key proteins (Akt, p70, mTOR, p38, JNK, ERK) will be lesser modulated in the quadriceps of patients with COPD compare to healthy controls. The phosphorylated as well as the total protein levels will be measured by western blot. The data will be presented as arbitrary units and compared with values obtained in healthy age-matched healthy controls. | 2 hours post-exercise | No |
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