Chronic Obstructive Pulmonary Disease (COPD) Clinical Trial
Official title:
Breathing-swallowing Interaction in Chronic Obstructive Pulmonary Disease (COPD) Patients Hospitalized in Intensive Care Unit for an Acute Exacerbation: Impact of Non Invasive Ventilation. Physiological Evaluation
In the investigators' knowledge there are no data about the impact of non invasive
mechanical ventilation on the breathing-swallowing interaction.
Our main objective is to evaluate breathing-swallowing interaction in Chronic Obstructive
Pulmonary Disease (COPD) patients hospitalized in intensive care unit for an acute
exacerbation, and evaluate the impact of using non invasive mechanical ventilation (NIV)
In healthy subjects previous studies showed that most swallows started during expiration and
were followed by expiration, a pattern believed to contribute to airway protection during
swallowing. However In healthy individuals, the occurrence of inspiration after swallows was
increased by hypercapnia or application of an inspiratory elastic load.
In a previous study the investigators have demonstrated that patients with neuromuscular
disorders exhibited piecemeal deglutition leading to an increase in the time needed to
swallow a water bolus, as well as occurrence of inspiration after nearly half the swallows.
These abnormalities which increased with the decreasing of respiratory muscle performances
may explain feeding difficulties. However in tracheostomized patients who could breathe
spontaneously, piecemeal deglutition and swallowing time per bolus were diminished by the
use of mechanical ventilation.
In the investigators' knowledge there are no data about the impact of non invasive
mechanical ventilation on the breathing-swallowing interaction.
The investigators' main objective is to evaluate breathing-swallowing interaction in Chronic
Obstructive Pulmonary Disease (COPD) patients hospitalized in intensive care unit for an
acute exacerbation, and evaluate the impact of using non invasive mechanical ventilation
(NIV)
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science
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