Proprioceptive Postural Control and Chronic Obstructive Pulmonary Disease (COPD)

Chronic Obstructive Pulmonary Disease Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01505543
• Other study ID #: 2012_SBrumagne_COPD
• Secondary ID: 1.5.104.03, G.06
• Status: Completed
• Phase: N/A
• First received: January 4, 2012
• Last updated: December 4, 2013
• Start date: January 2012
• Est. completion date: September 2012

Study information

• Verified date: July 2012
• Source: Katholieke Universiteit Leuven
• Contact: n/a
• Is FDA regulated: No
• Health authority: Belgium: Ethics Committee
• Study type: Observational

Clinical Trial Summary

Proprioceptive weighting changes may explain differences in postural control performance. In addition, the respiratory movement has a disturbing effect on postural balance. Postural balance seems to be impaired in individuals with respiratory disorders. Increased risk of falling is reported in individuals with chronic obstructive pulmonary disease. Besides the essential role of respiration, the diaphragm may also play an important role in the control of the trunk and postural balance.

The aim of the study is to clarify whether proprioceptive postural control is impaired in individuals with chronic obstructive pulmonary disease.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: September 2012
• Est. primary completion date: August 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 40 Years to 80 Years

Eligibility

Inclusion Criteria individuals with chronic obstructive pulmonary disease:

• Age: 40-80 years old

• Spirometry (post-bronchodilator) based diagnosis of COPD (GOLD criteria)

• Willingness to sign the informed consent

Inclusion Criteria healthy controls:

• Age: 40-80 years old

• No COPD (spirometry based: FEV1/FVC = 0.7 and FEV1 > 80%)

• Willingness to sign the informed consent

Exclusion Criteria:

• History of major trauma and/or major orthopedic surgery of the spine, the pelvis or the lower quadrant

• One of the following conditions: Parkinson, multiple sclerosis, stroke, history of vestibular disorder

• Respiratory disorder other than COPD

• a1-antitrypsin deficiency

• Known history of significant inflammatory disease other than COPD

• COPD exacerbation within 4 weeks prior to study

• Lung surgery

• Recent diagnosis of cancer

• Therapy with oral corticosteroids in the last 6 weeks

• Significant cardiovascular comorbidity

Study Design

Observational Model: Case Control, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Chronic Obstructive Pulmonary Disease
• Lung Diseases
• Lung Diseases, Obstructive
• Proprioceptive Postural Control
• Pulmonary Disease, Chronic Obstructive

Locations

Country	Name	City	State
Belgium	Katholieke Universiteit Leuven	Leuven	Vlaams-Brabant

Sponsors (2)

Lead Sponsor	Collaborator
Katholieke Universiteit Leuven	Universitaire Ziekenhuizen Leuven

Country where clinical trial is conducted

Belgium, 

References & Publications (1)

Janssens L, Brumagne S, Polspoel K, Troosters T, McConnell A. The effect of inspiratory muscles fatigue on postural control in people with and without recurrent low back pain. Spine (Phila Pa 1976). 2010 May 1;35(10):1088-94. doi: 10.1097/BRS.0b013e3181bee5c3. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Proprioceptive postural control	Center of pressure displacement (force plate) in standing in response to local muscle vibration on ankle and back muscles to specifically detect the role of proprioception in postural control.	6 months	No