Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
Comparison Between Spontaneous Breathing Trials Through Pressure-Support Ventilation or "T" Tube in the Weaning of Mechanical Ventilation in Patients With Chronic Obstructive Pulmonary Disease: A Randomized Controlled Trial
Weaning of mechanical ventilation (MV) is an essential part in management of patients with
Chronic Obstructive Pulmonary Disease (COPD) when critically ill. The best strategy to be
used has not been established.
Objective: To compare the Spontaneous Breathing Trial (SBT) in Pressure Support Ventilation
with SBT through "T" tube in weaning of MV in patients with COPD.
Design: Randomized Clinical Trial. Methods: This study will include patients with COPD,
admitted to the Intensive Care Unit of Hospital Nossa Senhora da Conceição, undergoing MV
for at least 48 hours. When considered by the care team ready for SBT, they will be
randomized to one of the following strategies: SBT in Pressure Support or SBT through "T"
Tube. The primary endpoint of this study will be the reduction in the days spent on MV.
Other outcomes measured will be mortality, extubation and success rate, time to weaning of
MV, length of ICU stay and incidence of tracheostomy.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Supportive Care
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