Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
Pulmonary Vascular Changes in Early Chronic Obstructive Pulmonary (MESA-COPD)
The Multi-Ethnic Study of Atherosclerosis (MESA) - Chronic Obstructive Pulmonary Disease (COPD) Study aims to characterize the pulmonary vascular changes and their biology in early COPD using imaging, gene expression profiling and peripheral cellular measures.
Chronic Obstructive Pulmonary Disease (COPD) is the third leading cause of death in the US
and will soon replace stroke as the third leading cause.
Translation of promising biological hypotheses of COPD pathogenesis to human populations
that may lead to new therapies is urgently needed. The vascular hypothesis of COPD was
articulated almost 50 years ago. Bench research on endothelial dysfunction in COPD is
evolving rapidly and has shown that acrolein in cigarette smoke causes endothelial apoptosis
and endothelial apoptosis is directly implicated in COPD pathogenesis. Clinical studies on
endothelial dysfunction and vascular changes in COPD are limited.
The proposed study is a longitudinal study of smokers nested among the MESA-Lung (AAAA7791)
and EMphysema and Cancer Action Project (EMCAP) Studies (AAAA6484), which together provide a
well-defined cohort of 4,617 participants with prior spirometry and CT measures.
The Multiethnic Study of Atherosclerosis - Chronic Obstructive Pulmonary Disease (MESA COPD
Study) has two main scientific purposes:
1. characterize the pulmonary vascular changes in COPD and their biology, and
2. propose novel pathways for new therapies in COPD.
MESA COPD is a longitudinal study of smokers nested within the MESA-Lung and EMCAP cohorts
of 360 participants (160 cases with mild, 60 cases with moderate and 40 cases with severe
COPD and 100 controls) who will be phenotyped with magnetic resonance (MR) pulmonary
angiography, pulmonary function testing, full-lung CT scans, serum Vascular Endothelial
Growth Factor (VEGF), cell assays and gene expression profiling. MESA COPD Study will
contribute improving the knowledge of early changes in COPD that may lead to novel
disease-modifying medical therapies and preventative strategies.
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Time Perspective: Prospective
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