Effects of Pursed-lip Breathing on Exercise Tolerance and Dynamic Hyperinflation in COPD

Chronic Obstructive Pulmonary Disease Clinical Trial

Official title:

Effects of Pursed-lip Breathing on Exercise Tolerance and Dynamic Hyperinflation in Chronic Obstructive Pulmonary Disease

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01173328
• Other study ID #: CEP/HUCFF/UFRJ 187/07
• Status: Completed
• Phase: N/A
• First received: July 19, 2010
• Last updated: July 30, 2010
• Start date: March 2007
• Est. completion date: October 2009

Study information

• Verified date: August 2008
• Source: Universidade Federal do Rio de Janeiro
• Contact: n/a
• Is FDA regulated: No
• Health authority: Brazil: National Committee of Ethics in Research
• Study type: Interventional

Clinical Trial Summary

Pursed-lip breathing (PLB) has been advocated to reduce respiratory rate and improve oxygen saturation in patients with chronic obstructive pulmonary disease (COPD) at rest. Although PLB is a strategy that potentially reduces expiratory flow limitation, there are only few studies addressing its effects on exercise.

This study aimed to assess the ability of PLB to change the breathing pattern, degree of dynamic hyperinflation (DH) and arterial oxygenation in COPD patients during exercise. Exercise tolerance was evaluated by endurance time and respiratory mechanics was evaluated by forced oscillation technique.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: October 2009
• Est. primary completion date: October 2009
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 40 Years and older

Eligibility

Inclusion Criteria:

• Clinical diagnosis of chronic obstructive pulmonary disease (COPD)

• Regular treatment at Clementino Fraga Filho University Hospital (UFRJ)

Exclusion Criteria:

• Exacerbation in the preceding 4 weeks

• SpO2<85% at peak exercise

• Other diseases that may contribute to dyspnea and exercise intolerance

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Chronic Obstructive Pulmonary Disease
• Lung Diseases
• Lung Diseases, Obstructive
• Pulmonary Disease, Chronic Obstructive

Intervention

Behavioral:
• Pursed-lip breathing
Pursed-lip breathing involves a nasal inspiration followed by expiratory blowing against partially closed lips, avoiding forceful exhalation.
• Normal Breathing

Locations

Country	Name	City	State
Brazil	Clementino Fraga Filho University Hospital	Rio de Janeiro

Sponsors (1)

Lead Sponsor	Collaborator
Universidade Federal do Rio de Janeiro

Country where clinical trial is conducted

Brazil, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Endurance time		within the first 01 hour	No
Secondary	inspiratory capacity		within the first 01 hour	No
Secondary	oxygen saturation		within the first 01 hour	No
Secondary	dyspnea		within the first 01 hour	No
Secondary	forced oscillation variables		within the first 01 hour	No