Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
Home Mechanical Ventilation in Patients With Chronic Obstructive Pulmonary Disease (COPD) Who Develop Nocturnal Hypercapnic Response Associated to Oxygen Therapy
The objective of this study is to evaluate the clinical benefits of home mechanical
ventilation associated to oxygen therapy in COPD patients with chronic respiratory failure
(CRF) who develop hypercapnia and nocturnal respiratory acidosis secondary to oxygen
administration.
We will include clinically stable COPD patients with hypercapnic CRF who develop a nocturnal
hypercapnic response to oxygen (PaCO2 increase on awakening, at night with oxygen, >10 mmHg
respect to PaCO2 breathing room air and awake). Obstructive sleep apnoea syndrome (OSAS)
will previously have been excluded.
Patients will be admitted to the Pneumology ward where a nocturnal pulsioxymetry breathing
oxygen therapy will be performed. Arterial blood gas samples will be taken at awakening
(7AM).
Patients who develop a hypercapnic response to oxygen will be randomised into 2 treatment
groups:
- Oxygen therapy group
- Home mechanical ventilation plus oxygen therapy group Home mechanical ventilation will
be performed with a bilevel pressure ventilator. Functional respiratory variables as
well as quality of life and sleep at onset and after 6 months treatment will be
compared.
The principal outcome will be the evolution of arterial blood gases (PaCO2) between the two
groups.
n/a
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