Chronic Obstructive Pulmonary Disease Clinical Trial
NCT number | NCT01091623 |
Other study ID # | 001/2005 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | March 23, 2010 |
Last updated | March 23, 2010 |
Start date | June 2005 |
Background. Exercise intolerance is one of the most devastating consequences of chronic
obstructive pulmonary disease (COPD). Abnormalities in peripheral muscle function such as
weakness and reduction in oxidative enzyme activities are commonly found in these patients
and may contribute to exercise intolerance.To evaluate whether a systemic weightlifting
exercise may improve exercise capacity better than endurance training, or a combined
training is more effective, the investigators compared three different training regimens,
endurance training alone, systemic weightlifting training alone or a combination of both
endurance and weightlifting training.
Methods.36 patients with stable COPD will be evaluated before and after a 4 month training
program. Each evaluation include a stepwise exercise test on an ergocycle up to the
individual maximal capacity during which minute ventilation (VE), oxygen consumption (VO2),
carbon dioxide production (VCO2), and arterial lactic acid concentration will be measured
and the peripheral muscle strength will be determined with the one repetition maximum for
eight different muscle groups. Percutaneous needle muscle biopsy from the M.vastus lateralis
will be performed before and after the training period in order to determine the fiber-type
proportions. Patients are assigned to one of the following three groups (1) endurance
training consisted of 20 min exercise sessions on a calibrated ergocycle two times a week,
with a target training intensity at 60% of individual maximum oxygen uptake, (2) systemic
weightlifting training two times a week with eight different exercises, each session consist
of 15 repetitions of each muscle group, (3) combination of endurance training and systemic
weightlifting training.
Statistical analysis. Baseline data for all patients enrolled in the study will be compared
by one-way analysis of variance for the three study groups. Results before and after
training will be analyzed by two- way analysis of variance.
Status | Completed |
Enrollment | 36 |
Est. completion date | |
Est. primary completion date | January 2010 |
Accepts healthy volunteers | |
Gender | Both |
Age group | 40 Years to 75 Years |
Eligibility |
Inclusion Criteria: 1. age: 40-75 years 2. mild to moderate COPD patients according to the staging schemata of the austrian society of lung and tuberculosis disease (ÖGLUT) Exclusion Criteria: 1. acute infection 2. reduced left ventricular function 3. myocardial infarction 4. stroke 5. severe pulmonary hypertension (mpap>40mmHg) 6. insufficient treated hypertension RR>160/95) (participation with sufficient treatment ) 7. severe cardiac arrhythmia 8. malignant diseases 9. severe osteoporosis 10. nicotine abuses 11. other severe chronic diseases |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label
Country | Name | City | State |
---|---|---|---|
Austria | Medical University of Vienna | Vienna |
Lead Sponsor | Collaborator |
---|---|
Medical University of Vienna |
Austria,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | increase of exercise capacity |
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