Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
Randomized Controlled Trial on the Cardiovascular Effects of Lung Volume Reduction Surgery in Patients With Chronic Obstructive Pulmonary Disease
A randomised controlled trial will be performed to evaluate the effects of lung volume
reduction surgery (LVRS) in patients with COPD on systemic inflammation, oxidative stress,
endothelial function, arterial stiffness and blood pressure. We hypothesize that LVRS will
lead to a reduction of systemic inflammation, oxidative stress, arterial stiffness and blood
pressure and to improved endothelial function.
For this purpose 30 patients with severe/very severe COPD (GOLD III-IV) and pulmonary
emphysema who are to undergo LVRS will be randomised to one of two groups: group 1 receiving
immediate LVRS and group 2 receiving LVRS after a delay of 3 months.
Measures of systemic inflammation, oxidative stress, endothelial function, arterial
stiffness and blood pressure will be measured at baseline and 3 months after surgery and no
surgery, respectively (group 2 receiving surgery only after a delay of 3 months will serve
as control group) to investigate the effects of LVRS on the described outcomes.
Not desired ;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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