Chronic Obstructive Pulmonary Disease (COPD) Clinical Trial
— ESTIMOfficial title:
Study of the Benefits of Lower Limb Electrostimulation Training on Muscular Parameters and Minute Ventilation During Exercise in Severe and Deconditioned COPD Patients.
Verified date | October 2012 |
Source | Laval University |
Contact | n/a |
Is FDA regulated | No |
Health authority | Canada: Health Canada |
Study type | Interventional |
This study was designed to test the following hypothesis:
The benefit of electrostimulation training will be greater than sham stimulation training in
term of muscle strength and mass (muscle hypertrophy), exercise tolerance, reduction of
ventilation during exercise and quality of life in COPD patients
Status | Completed |
Enrollment | 23 |
Est. completion date | June 2009 |
Est. primary completion date | May 2009 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 55 Years to 80 Years |
Eligibility |
Inclusion Criteria: - COPD - FEV1 < 60% predicted value and FEV1/ FVC < 70% - 6-minute walking distance < 400 m Exclusion Criteria: - Patients suffering from cardiovascular, neurological, skeletal muscle, or any other condition that could alter their capacity to perform the exercise test - Patients taking systemic corticosteroids on a daily basis (patients having received systemic steroids for the treatment of up to two exacerbations in the preceding year and those on inhaled steroids will be allowed) - Patients with room air PaO2 < 60 mm Hg will be excluded. |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Canada | Hôpital Laval | Quebec city | Quebec |
Lead Sponsor | Collaborator |
---|---|
Laval University |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in the strength of the quadriceps over the 6-week electrostimulation program. | 6 to 8 weeks | No | |
Secondary | Ventilation at iso-time during an endurance shuttle walkMuscle | 6 to 8 weeks | No | |
Secondary | hypertrophying/atrophying pathways | 6 to 8 weeks | No | |
Secondary | Muscle aerobic capacity: fibre-typing, oxydative enzymes, muscle capillarization | 6 to 8 weeks | No |
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